Category: 119431-25-3

Layer, Richard T. et al. published their research in Pharmacology, Biochemistry and Behavior in 1995 | CAS: 119431-25-3

1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Category: piperidines

Antidepressant-like actions of the polyamine site NMDA antagonist, eliprodil (SL-82.0715) was written by Layer, Richard T.;Popik, Piotr;Olds, Tia;Skolnick, Phil. And the article was included in Pharmacology, Biochemistry and Behavior in 1995.Category: piperidines This article mentions the following:

Functional N-methyl-D-aspartate (NMDA) antagonists including competitive antagonists, glycine partial agonists, and use-dependent channel blockers exhibit antidepressant-like actions in preclin. models. The present study examined the effects of eliprodil (SL-82.0715), an NMDA antagonist acting at polyamine sites, in behavioral and neurochem. tests predictive of antidepressant activity. In mice, eliprodil produced a dose-dependent reduction in immobility in the forced swim test, but was inactive in the tail suspension test. Chronic treatment with eliprodil produced both a significant down-regulation of 尾-adrenoreceptors and a reduction in the potency of glycine to inhibit [3H]5,7-dichlorokynurenic acid binding to strychnine-insensitive glycine receptors in neocortical membranes. In toto, these data indicate that like other NMDA antagonists, eliprodil possess antidepressant-like actions in preclin. tests predictive of clin. efficacy. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3Category: piperidines).

1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Bespalov, Anton Y. et al. published their research in Pharmacology, Biochemistry and Behavior in 1998 | CAS: 119431-25-3

1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Recommanded Product: 119431-25-3

Interactions between N-methyl-D-aspartate receptor antagonists and the discriminative stimulus effects of morphine in rats was written by Bespalov, Anton Y.;Beardsley, Patrick M.;Balster, Robert L.. And the article was included in Pharmacology, Biochemistry and Behavior in 1998.Recommanded Product: 119431-25-3 This article mentions the following:

N-methyl-D-aspartate (NMDA) receptor antagonists alter some pharmacol. and behavioral effects of acute and chronic opioid administration. The interactions of NMDA antagonists with the discriminative stimulus properties of morphine were studied in adult male Long-Evans rats. The rats were trained to discriminate 3.2 mg/kg of s.c. morphine from water under a 2-lever fixed-ratio 10 schedule of food reinforcement. During test sessions, i.p. injections of the non-competitive NMDA receptor antagonist dizocilpine (0.03-0.2 mg/kg), the competitive antagonists NPC-17742 (1-16 mg/kg) and SDZ 220-581 (0.1-3 mg/kg), the polyamine site antagonist eliprodil (3-17.3 mg/kg), the glycine site partial agonist (+)-HA-966 (3-56 mg/kg), and the nonselective glutamate antagonist kynurenic acid (30-150 mg/kg) were coadministered with s.c. morphine (1-3.2 mg/kg; interaction tests) or water (generalization tests). In the generalization tests, none of the compounds completely substituted for morphine. Concurrent administration of morphine and NMDA antagonists did not greatly alter the discriminative stimulus properties of morphine. Various doses of NPC-17742, SDZ 220-581, or (+)-HA-966 somewhat increased the levels of morphine-appropriate lever selection, whereas some attenuation of morphine lever selection was obtained when morphine was coadministered with eliprodil. Thus, NMDA antagonists have minimal interactions with the discriminative stimulus effects of morphine. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3Recommanded Product: 119431-25-3).

1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Recommanded Product: 119431-25-3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Chenard, B. L. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 1993 | CAS: 119431-25-3

1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Recommanded Product: 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol

Oxindole N-methyl-D-aspartate (NMDA) antagonists was written by Chenard, B. L.;Butler, T. W.;Shalaby, I. A.;Prochniak, M. A.;Koe, B. K.;Fox, C. B.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1993.Recommanded Product: 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol This article mentions the following:

Replacement of the phenol group in the noncompetitive NMDA antagonist ifenprodil with oxindole results in a new series of nontraditional NMDA antagonists. Thus, (hydroxypiperdinylethyl)oxindoles I were prepared by Friedel-Crafts acylation of oxindole II with MeCHClCOCl, nucleophilic substitution with 4-benzylpiperidine, and reduction with NaBH4 in EtOH. In combination with threo relative stereochem., improved NMDA antagonist potency and selectivity may be achieved. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3Recommanded Product: 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol).

1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Recommanded Product: 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Bespalov, Anton Y. et al. published their research in Pharmacology, Biochemistry and Behavior in 1998 | CAS: 119431-25-3

1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Recommanded Product: 119431-25-3

Interactions between N-methyl-D-aspartate receptor antagonists and the discriminative stimulus effects of morphine in rats was written by Bespalov, Anton Y.;Beardsley, Patrick M.;Balster, Robert L.. And the article was included in Pharmacology, Biochemistry and Behavior in 1998.Recommanded Product: 119431-25-3 This article mentions the following:

N-methyl-D-aspartate (NMDA) receptor antagonists alter some pharmacol. and behavioral effects of acute and chronic opioid administration. The interactions of NMDA antagonists with the discriminative stimulus properties of morphine were studied in adult male Long-Evans rats. The rats were trained to discriminate 3.2 mg/kg of s.c. morphine from water under a 2-lever fixed-ratio 10 schedule of food reinforcement. During test sessions, i.p. injections of the non-competitive NMDA receptor antagonist dizocilpine (0.03-0.2 mg/kg), the competitive antagonists NPC-17742 (1-16 mg/kg) and SDZ 220-581 (0.1-3 mg/kg), the polyamine site antagonist eliprodil (3-17.3 mg/kg), the glycine site partial agonist (+)-HA-966 (3-56 mg/kg), and the nonselective glutamate antagonist kynurenic acid (30-150 mg/kg) were coadministered with s.c. morphine (1-3.2 mg/kg; interaction tests) or water (generalization tests). In the generalization tests, none of the compounds completely substituted for morphine. Concurrent administration of morphine and NMDA antagonists did not greatly alter the discriminative stimulus properties of morphine. Various doses of NPC-17742, SDZ 220-581, or (+)-HA-966 somewhat increased the levels of morphine-appropriate lever selection, whereas some attenuation of morphine lever selection was obtained when morphine was coadministered with eliprodil. Thus, NMDA antagonists have minimal interactions with the discriminative stimulus effects of morphine. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3Recommanded Product: 119431-25-3).

1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Recommanded Product: 119431-25-3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Chenard, B. L. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 1993 | CAS: 119431-25-3

1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Recommanded Product: 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol

Oxindole N-methyl-D-aspartate (NMDA) antagonists was written by Chenard, B. L.;Butler, T. W.;Shalaby, I. A.;Prochniak, M. A.;Koe, B. K.;Fox, C. B.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1993.Recommanded Product: 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol This article mentions the following:

Replacement of the phenol group in the noncompetitive NMDA antagonist ifenprodil with oxindole results in a new series of nontraditional NMDA antagonists. Thus, (hydroxypiperdinylethyl)oxindoles I were prepared by Friedel-Crafts acylation of oxindole II with MeCHClCOCl, nucleophilic substitution with 4-benzylpiperidine, and reduction with NaBH4 in EtOH. In combination with threo relative stereochem., improved NMDA antagonist potency and selectivity may be achieved. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3Recommanded Product: 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol).

1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Recommanded Product: 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem