Category: 1174020-64-4

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Recommanded Product: tert-Butyl 4-((1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate, Which mentioned a new discovery about 1174020-64-4

Compound 1, a potent and irreversible inhibitor of beta-lactamases, is in clinical trials with beta-lactam antibiotics for the treatment of serious and antibiotic-resistant bacterial infections. A short, scalable, and cost-effective route for the production of this densely functionalized polycyclic molecule is described.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Recommanded Product: tert-Butyl 4-((1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 1174020-64-4

Reference：
Piperidine – Wikipedia,
Piperidine | C5H23836N – PubChem

Electric Literature of 1174020-64-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1174020-64-4, Name is tert-Butyl 4-((1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate, molecular formula is C17H28N4O5. In a Patent，once mentioned of 1174020-64-4

beta-Lactamase inhibiting compounds, therapeutic methods of using the beta-lactamase inhibiting compounds, particularly in combination with beta-lactam antibiotics and pharmaceutical compositions thereof are disclosed. The beta-lactamase inhibiting compounds are suitable for oral administration.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 1174020-64-4 is helpful to your research. Electric Literature of 1174020-64-4

Reference：
Piperidine – Wikipedia,
Piperidine | C5H23838N – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1174020-64-4, name is tert-Butyl 4-((1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate, introducing its new discovery. Application In Synthesis of tert-Butyl 4-((1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate

Second-generation beta-lactamase inhibitors containing a diazabicyclooctane (DBO) scaffold restore the activity of beta-lactams against pathogenic bacteria, including those producing class A, C, and D enzymes that are not susceptible to first-generation inhibitors containing a beta-lactam ring. Here, we report optimization of a synthetic route to access triazole-containing DBOs and biological evaluation of a series of 17 compounds for inhibition of five beta-lactamases representative of enzymes found in pathogenic Gram-negative bacteria. A strong correlation (Spearman coefficient of 0.87; p = 4.7 ¡Á 10-21) was observed between the inhibition efficacy of purified beta-lactamases and the potentiation of beta-lactam antibacterial activity, indicating that DBO functionalization did not impair penetration. In comparison to reference DBOs, avibactam and relebactam, our compounds displayed reduced efficacy, likely due to the absence of hydrogen bonding with a conserved asparagine residue at position 132. This was partially compensated for by additional interactions involving certain triazole substituents.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1174020-64-4 is helpful to your research. Application In Synthesis of tert-Butyl 4-((1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H23833N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1174020-64-4,tert-Butyl 4-((1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of the product of step 2 (1.455 g, 3.95 mmol; theoretical yield of step 2) in dry pyridine (30 mL) was added sulfur trioxide pyridine complex (3.2 g, 20.11 mmol) at room temperature under nitrogen. The resulting thick mixture was stirred over the weekend.The reaction was filtered and the white insoluble solids were washed well with dichloromethane. The filtrate was concentrated in vacuo. The residue was further azeotroped with toluene to remove excess pyridine to afford the title compound which was used without purification in the next step., 1174020-64-4

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Reference£º
Patent; MERCK & CO., INC.; WO2009/91856; (2009); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem