Category: 1158759-03-5

1158759-03-5, tert-Butyl ((4-methylpiperidin-4-yl)methyl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 8: l-Benzyl-3-(2,3-dichlorophenyl)-5-methyl-l//-pyrazolo[3,4- 1158759-03-5, The synthetic route of 1158759-03-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; RELAY THERAPEUTICS, INC.; D.E. SHAW RESEARCH, LLC; WALTERS, W., Patrick; LESCARBEAU, Andre; KELLEY, Elizabeth, H.; SHORTSLEEVES, Kelley, C.; TAYLOR, Alexander, M.; PIERCE, Levi Charles, Thomas; MURCKO, Mark, Andrew; GIORDANETTO, Fabrizio; GREISMAN, Jack, Benjamin; MARAGAKIS, Paul; BHAT, Sathesh; KONZE, Kyle; DAHLGREN, Markus, Kristofer; THERRIEN, Eric; (0 pag.)WO2019/165073; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1158759-03-5, tert-Butyl ((4-methylpiperidin-4-yl)methyl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 4d (0.35 g, 1.13 mmol), tert-butyl ((4-methylpiperidin-4-yl)methyl)carbamate (0.39 g, 1.70 mmol) DIEA (0.36 g, 2.83 mmol) was added to DMSO (10 mL) and stirred at 100 C for 2 h. The reaction solution was added water (10 mL), EA extraction (10 mL ¡Á 2), the combined organic phases were washed with brine (50 mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure, the residue was purified by column chromatography to give compound 4e (0.15 g, 27%), 1158759-03-5

The synthetic route of 1158759-03-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JACOBIO PHARMACEUTICALS CO., LTD; MA, CUNBO; GAO, PANLIANG; CHU, JIE; WU, XINPING; WEN, CHUNWEI; KANG, DI; BAI, JINLONG; PEI, XIAOYAN; (171 pag.)TW2019/25186; (2019); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1158759-03-5,tert-Butyl ((4-methylpiperidin-4-yl)methyl)carbamate,as a common compound, the synthetic route is as follows.

Step b: To a solution of 6-chloro-1-methylpyridin-2(1H)-one (55 mg, 0.383 mmol), DIPEA (200 jiL, 1.15 mmol), and tert-butyl ((4-methylpiperidin-4-yl)methyl)carbamate (96 mg, 0.42 1 mmol) in DMF (1 mL) was radiated in a microwave reactor for 2 h at 140 C. After cooling to RT, the reaction mixture was diluted with EtOAc. The organic layer was washed with sat. aq. NH4C1 (2 x) followed by brine. The organic layer was dried over Mg504, filtered, and the volatiles were removed under reduced pressure. The residue was purified by silica chromatography (0 to 100% gradient of EtOAc/heptane) to give tert-butyl ((4-methyl-i -(1- methyl-6-oxo- 1 ,6-dihydropyridin-2-yl)piperidin-4-yl)methyl)carbamate (53 mg, 0.158 mmol). ?H NMR (400 MHz, DMSO-d6) oe ppm 7.33 (dd, J=8.9, 7.4 Hz, 1 H), 6.94 (t, J=6.3 Hz, 1 H), 6.10- 6.04 (m, 1 H), 3.35 (s, 3 H), 2.95-2.85 (m, 4 H), 2.77 (s, 2 H), 1.56-1.47 (m, 2 H), 1.42-1.30 (m, ii H), 0.89 (s, 3 H). MS m/z 336.6 (M+H)

1158759-03-5, As the paragraph descriping shows that 1158759-03-5 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; CHEN, Zhuoliang; FORTANET, Jorge Farcia; LAMARCHE, Matthew J.; SENDZIK, Martin; TAMEZ, JR., Victoriano; YU, Bing; (237 pag.)WO2016/203405; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1158759-03-5, tert-Butyl ((4-methylpiperidin-4-yl)methyl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step a: To a solution of 2-chloro-4-((4-methoxybenzyl)oxy)pyrimidine (118 mg, 0.5 19 mmol), prepared according to the methods in W0201 1022440, in DMF (50 mL) was added tert-butyl ((4-methylpiperidin-4-yl)methyl)carbamate (130 mg, 0.5 19 mmol). The reaction stirred for 48 h and was diluted in EtOAc:water (1:1, 100 mL). The mixture was extracted with EtOAc (3 x) and the combined organic extracts were washed with brine (3 x), dried over Mg504, filtered, and concentrated under reduced pressure to afford crude tert-butyl ((1 -(4-((4- methoxybenzyl)oxy)pyrimidin-2-yl)-4-methylpiperidin-4-yl)methyl)carbamate, as a yellow oil (202 mg) which was used without further purification. MS m/z 443 (M+H).

1158759-03-5, The synthetic route of 1158759-03-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; CHEN, Zhuoliang; FORTANET, Jorge Farcia; LAMARCHE, Matthew J.; SENDZIK, Martin; TAMEZ, JR., Victoriano; YU, Bing; (237 pag.)WO2016/203405; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem