Category: 113617-63-3

Determination of 12 quinolones in honey by vortex-assisted dispersive liquid liquid microextraction performed in syringe based on deep eutectic solvent combine with ultra performance liquid chromatography-mass spectrometry was written by Wang, Yixia;Zhao, Sijun;Yang, Linyan;Liu, Chang;Wang, Hongyu;Li, Daowen;Zhang, Wei;Li, Liuan;Song, Cuiping;Li, Cun. And the article was included in European Food Research and Technology in 2022.COA of Formula: C19H20F3N3O3 This article mentions the following:

A novel vortex-assisted dispersive liquid-liquid microextraction method based on deep eutectic solvent (VA-DLLME-DES) completed in syringe has been established to extract 12 quinolones from honey. This method is an improvement of traditional DLLME. In this work, the green DES prepared with heptanoic acid and thymol was used for extractant rather than traditional organic extraction solvent. Without centrifugation, the phases were separated in the way of removing aqueous phase by pushing the syringe and extractant phase was collected for ultra performance liquid chromatog.-mass spectrometry (UPLC-MS) anal. The stability of DES and some exptl. parameters (type, molar ratios and volume of extraction solvent, type and volume of dispersant, vortex time and effect of pH and NaCl) were evaluated. In the range of 2-100 ng/mL, the proposed method showed good linearities (r² ranged from 0.996 to 0.999). The extraction recoveries were obtained in the range of 75.01%-117.05% and relative standard deviations were less than 13.83% for inter- (n = 6) and intra-day (n = 3) precisions. The limits of detection and quantification were 3 ng g^-1 and 10 ng g^-1, resp. The developed method with the advantages of simple operation, short extraction time and less consumption organic solvent provides a tech. idea for green, simple and time-saving sample preparation methods. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas: 113617-63-3COA of Formula: C19H20F3N3O3).

1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas: 113617-63-3) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.COA of Formula: C19H20F3N3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Improvement and validation of rapid simultaneous analysis method for veterinary drugs by LC-MS/MS (part 2) was written by Fujii, Yoshiaki;Kaga, Takero;Hosokawa, Aoi;Nishimura, Kazuhiko. And the article was included in Hokkaidoritsu Eisei Kenkyushoho in 2019.Application of 113617-63-3 This article mentions the following:

Veterinary drugs (animal drugs) are drugs used for the treatment and prevention of diseases of livestock and households, and play an important role in the stable supply of livestock products. This paper discusses improvement and validation of rapid simultaneous anal. method for veterinary drugs by liquid chromatog.-mass spectrometry/mass spectrometry. The substances and medicines to be examined, the sources of standard products and LC-MS/MS conditions were given. The calibration curve was prepared using the matrix standard solution, and validity evaluation test was carried out. In this anal. method, every methods were simplified and good results were obtained compare to previous report. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas: 113617-63-3Application of 113617-63-3).

1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas: 113617-63-3) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Application of 113617-63-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Validation of simultaneous analytical method of veterinary drugs in foods using new automatic pretreatment equipment was written by Yatsukawa, Yoichi;Kusuno, Daisuke;Matsuda, Takahiro;Kobayashi, Kazuhiro;Ohba, Tetsuro. And the article was included in Shokuhin Eiseigaku Zasshi in 2017.Safety of 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid This article mentions the following:

New automatic pretreatment equipment (FASVED; food automatic anal. systems for veterinary drugs) was developed. FASVED consists of ten main units: reagent dispenser, homogenizer, transfer hand, lid opening/closing device, centrifugal separator, pipet, shaker, column purification device, centrifugal evaporator and cooling device, and it is capable of freely combining operations by these units. A validation study was performed on two methods for determination of 178 veterinary drugs in livestock products, swine muscle, egg and shrimp, according to the method validation guideline of the Ministry of Health, Labour and Welfare of Japan. The numbers of analytes that satisfied the criteria of the guideline were 148 in swine muscle, 160 in egg and 151 in shrimp. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas: 113617-63-3Safety of 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid).

1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas: 113617-63-3) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Safety of 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Cropping system exerts stronger influence on antibiotic resistance gene assemblages in greenhouse soils than reclaimed wastewater irrigation was written by Liu, Yuan;Neal, Andrew L.;Zhang, Xiaoxian;Fan, Haiyan;Liu, Honglu;Li, Zhongyang. And the article was included in Journal of Hazardous Materials in 2022.Quality Control of 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid This article mentions the following:

The effects of reclaimed wastewater (RW) irrigation on the spread of antibiotic resistance genes (ARGs) in soil is modulated by a myriad of biotic and abiotic factors and their relative significance remains vague. We compared microbial communities, assemblages of genes associated with microbial resistance to antibiotics, biocides and metals, and insertion sequences (ISs) in soils following 16 years of irrigation with groundwater (GW), RW or alternately with GW and RW in two greenhouses with different cropping systems, using shotgun metagenome sequencing. The results showed that cropping system exerted greater influence than irrigation on the profile of ISs and resistance genes. This influence was most strongly associated with concentrations of copper, mercury and perfloxacin in the soils. There was no significant difference in soil ARG profiles between continuous RW irrigation and alternating GW and RW irrigation. Proteobacteria, Actinobacteria and Firmicutes and a limited number of ISs were closely associated with the detected ARGs. Most ARGs were found to co-occur with metal and biocide resistance genes through the mechanism of efflux pumps. These findings highlight the significance of understanding and improving crop management in mitigating the dissemination of ARGs in soils irrigated with RW. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas: 113617-63-3Quality Control of 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid).

1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas: 113617-63-3) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Quality Control of 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

A quadruple-labeling luminescence strategy for multiplexed immunoassay of 51 drugs in milk with an automated pretreatment system was written by Zhang, Yaqing;Chang, Xiaoxi;Wang, Xin;Tao, Xiaoqi. And the article was included in Analytical Methods in 2019.Computed Properties of C19H20F3N3O3 This article mentions the following:

In this study, a novel combination of quadruple-labeling luminescence strategy multiplexed immunoassay (QLL-MIA) and an automated pretreatment system for simultaneous extraction and determination of 20 fluoroquinolones (FQs), 15 β-lactams, 15 sulfonamides (SAs), and chloramphenicol (CAP) in milk was developed. The strategy integrated 2 fluorescence probes, and 2 chemiluminescence probes to achieve signal separation, and a new combination of a nucleic acid extraction system and immunomagnetic beads (IMBs) as the automated pretreatment system to achieve simultaneous determination of 51 drugs. Taking advantage of automated pretreatment system for concentrating milk sample with 5 times and saving the extraction time, the limits of detection (LODs) for FQs, β-lactams, SAs, and CAP in the QLL-MIA range from 29.1 ng L^-1 for ciprofloxacin (CIP) to 8000.0 ng L^-1 (8.0μg L^-1) for trovafloxacin (TRO), 20.0 ng L^-1 for ceftiofur (CEF) to 3409.1 ng L^-1 (3.4μg L^-1) for cephalexin (CEL), 8.6 ng L^-1 for sulfadimethoxine (SDM) to 328.2 ng L^-1 (0.3μg L^-1) for sulfadiazine (SDZ), and 6.0 ng L^-1 for CAP. The recoveries ranged from 80.6% to 105.5% at a fortified concentration of LOD and 2 LOD, with a coefficient of variation <15%. Anal. of field milk samples by the combination of QLL-MIA and the automated pretreatment system (the developed QLL-MIA) was in accordance with that of liquid chromatog. coupled with tandem mass spectrometry (LC-MS/MS). The above results demonstrated that the developed QLL-MIA could simultaneously screen trace amounts of FQs, β-lactams, SAs, and CAP in field samples, suitable for high-throughput screening of low-mol. weight contaminants. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas: 113617-63-3Computed Properties of C19H20F3N3O3).

1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas: 113617-63-3) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Computed Properties of C19H20F3N3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Simultaneous determination of multi-class antibiotics and steroid hormones drugs in livestock and poultry faeces using liquid chromatography-quadrupole time-of-flight mass spectrometry was written by Wang, Kewen;Wang, Xue;Xu, Zhenzhen;Yang, Shuming. And the article was included in Food Additives & Contaminants, Part A in 2020.Formula: C19H20F3N3O3 This article mentions the following:

A method for simultaneous determination of multi-class antibiotics and steroid hormone anal. in faeces of livestock and poultry was developed using liquid chromatog.-quadrupole time-of-flight mass spectrometry (LC-QTOF MS). An inhouse database was built for 156 detected drugs using Personal Compound Database Library software (PCDL) including compound name, monoisotopic mass, chem. formula, RT, chem. structure and three CID MS/MS spectra. The linearity result showed that all the drugs exhibited good linearity with determination coefficients (R2) higher than 0.99. The drug recoveries and their RSDs for all three faeces samples (pig, cattle and chicken) were tested and 81, 96 and 92 drugs were chosen for anal. in pig, cattle and chicken faeces, resp. Further validation showed that 73 veterinary drugs in all three kinds of faeces samples can be quantified in one anal. run. This work shows that qual. and quant. anal. using LC-QTOF MS represents a simple, sensitive, low-cost and high-throughput methodol. in routine laboratory analyses. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas: 113617-63-3Formula: C19H20F3N3O3).

1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas: 113617-63-3) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Formula: C19H20F3N3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics