Category: 113310-52-4

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Application In Synthesis of 4-(Piperidin-4-yl)aniline, Which mentioned a new discovery about 113310-52-4

The present invention relates to compounds of the formula: STR1 wherein R is H or alkyl; Y1 is –CH= or –N=; and Y2 –CH=, –C(OH)=, –C(NO2)=, –C(NH2)=, –C(Hal)=, –N=; X is cycloalkenyl; bicyclo[2.2.1]hept-2-yl, optionally substituted by phenyl-2-oxo-5 -methoxymethyl-oxazolidinyl; bicyclo[2.2.1]-hept-5 -en-2-yl; adamantyl; or cycloalkyl or piperidinyl, optionally substituted by amino, alkyl, –CN, oxo hydroxyimino, ethylenedioxy or by –OR1, R1 is –CH(C6 H5)2, –(CH2)n C6 H5, alkyl, H, –(CH2)n NHCOCH3, –(CH2)n NH2, –(CH2)n CN, –(CH2)n SCH3 –(CH2)n SO2 CH3, –CO-lower-alkyl, –COC6 H5, optionally substituted by oxazolidine; or by =CR2 R3, R2 is alkyl R3 is H, –CN, alkyl, phenyl or COO-alkyl; or by –(CH2)n R4 R4 is –CN, amino, –NHCOCH3, –COC6 H5 Hal, phenyl or hydroxy; or by –COR5, R5 is alkyl, –CH=CH–C6 H5, –C6 H5, –C6 H5 CF3 or –O-alkyl; or by –NR6 R7, R6 is or –COCH3 ; R7 is –COCH3, benzyl or –(CH2)n NHCOC6 H4 Hal; and n is 1-3; These can be used for the prevention or control of depressive, panic and anxiety states, and treatment of certain cognitive disorders and neurodegenerative diseases.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Application In Synthesis of 4-(Piperidin-4-yl)aniline, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 113310-52-4

Reference：
Piperidine – Wikipedia,
Piperidine | C5H10513N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， SDS of cas: 113310-52-4, Which mentioned a new discovery about 113310-52-4

The NQO1-substrate NAMPT inhibitor, disclosed by the invention can simultaneously target, and, active small molecule compounds and pharmaceutical uses, of the compounds or pharmaceutical compositions in preparation of anti-tumor drugs, and the compounds or pharmaceutical compositions can inhibit. activity NQO1 and consume IIA while simultaneously inhibiting NAMPT active compounds or pharmaceutically acceptable salt NQO1 solvate/NAMPT prodrugs, ester NQO1 racemates and isomers and pharmaceutical compositions containing such compounds . The invention discloses a pharmaceutical composition containing the compounds and NAMPT as and a pharmaceutical composition containing the compounds and a pharmaceutical composition containing the compounds or pharmaceutical, compositions thereof NAD+ NAD. + The biological synthesis, shows stronger tumor suppressor activity . and meanwhile, the o-quinone derivative targeting NQO1 and NAMPT or the pharmaceutical composition thereof has a wide application prospect, and is expected to be an antitumor drug. (by machine translation)

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, SDS of cas: 113310-52-4, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 113310-52-4

Reference：
Piperidine – Wikipedia,
Piperidine | C5H10515N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， category: piperidines, Which mentioned a new discovery about 113310-52-4

Described are cancer therapies and anti-cancer compounds. In particular, disclosed are ihibitors of Ack1 tyrosine kinase and their use in the treatment of cancer. Methods of screening for new Ack1 tyrosine kinase inhibitors are also disclosed. In specifc example, compound having Formula I through IV are disclosed.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 113310-52-4, help many people in the next few years.category: piperidines

Reference：
Piperidine – Wikipedia,
Piperidine | C5H10520N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Formula: C11H16N2, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 113310-52-4, Name is 4-(Piperidin-4-yl)aniline, molecular formula is C11H16N2. In a Article, authors is Gandhi, Viraj B.，once mentioned of 113310-52-4

Through conformational restriction of a benzamide by formation of a seven-membered hydrogen-bond with an oxindole carbonyl group, a series of PARP inhibitors was designed for appropriate orientation for binding to the PARP surface. This series of compounds with a 3-oxoisoindoline-4-carboxamide core structure, displayed modest to good activity against PARP-1 in both intrinsic and cellular assays. SAR studies at the lactam nitrogen of the pharmacophore have suggested that a secondary or tertiary amine is important for cellular potency. An X-ray structure of compound 1e bound to the protein confirmed the formation of a seven-membered intramolecular hydrogen bond. Though revealed previously in peptides, this type of seven-membered intramolecular hydrogen bond is rarely observed in small molecules. Largely due to the formation of the intramolecular hydrogen bond, the 3-oxoisoindoline-4-carboxamide core structure appears to be planar in the X-ray structure. An additional hydrogen bond interaction of the piperidine nitrogen to Gly-888 also contributes to the binding affinity of 1e to PARP-1.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. Formula: C11H16N2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H10511N – PubChem

113310-52-4, 4-(Piperidin-4-yl)aniline is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Substrates NT1-003 (80 mg, 0.32 mmol) and NT1-004 (28.4 mg, 0.32 mmol) were mixed in a microwave tube with EtOH (1 mL). Then 0.1NHC1 (1 mL) was added to the tube. The vessel was sealed and heated to 150 C for 40 minutes. The solvent was removed under reduced pressure, the residue washed with DCM, and filtered to afford 5 -chloro-N2-(4-Q,iperidin-4-yl)phenyl)-1V4-((tetrahydrofuran-2-yl)methyl)pyrimidine-2,4- diamine (NT1-005) as a peach solid (90 mg, 72.0%), mp 160 C (dec.). HPLC 85.6% [R = 7.51 mm, 30% CH3OH in 0.1% TFA water 20 mm]. ?H NMR (400 MHz, Methanol-d4) oe 7.94 (s,1H), 7.49 (d, J= 8.2 Hz, 2H), 7.35 (d, J= 8.4 Hz, 2H), 4.16 (p, J= 6.2 Hz, 1H), 3.86-3.68 (m,2H), 3.65 -3.46 (m, 4H), 3.22-3.09 (m, 2H), 3.00-2.90 (m, 1H), 2.14- 1.82 (m, 8H), 1.69-1.58(m, 1H). ?3C NMR (101 MHz, Methanol-d4) oe 159.20, 151.43, 141.84, 139.72, 135.04, 127.16,122.99, 105.19, 76.74, 67.63, 45.23, 44.15, 39.15, 29.68, 28.54, 25.01. LC-MS (ESI+) m/z388.18965 (M+H) HRMS (ESI+) m/z calculated for C2oH26ClN5O(M+H)388.1899, found,388.1900.

113310-52-4, 113310-52-4 4-(Piperidin-4-yl)aniline 22047841, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; MAHAJAN, Nupam, P.; MAHAJAN, Kiran, N.; LAWRENCE, Nicholas, J.; LAWRENCE, Harshani, R.; WO2015/21149; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem