Category: 1123-40-6

Application of 1123-40-6, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1123-40-6, name is 4,4-Dimethylpiperidine-2,6-dione. In an article£¬Which mentioned a new discovery about 1123-40-6

Regioselective nitration of aromatics under phase-transfer catalysis conditions

Mononitration of aromatics was performed in a two-phase system using phase-transfer catalyst. The most advantageous conditions for the nitration were determined (temperature, reaction time, the type and amount of phase transfer catalyst, nitrification strength of the nitro-sulfuric acid). From the results, a significant improvement in the selectivity and conversion of the nitration of xylene was observed: the ratio of 4-nitro-m-xylene to 2-nitro-m-xylene was unprecedented increased up to 91.3%:7.7%, the ratio of 4-nitro-o-xylene to 3-nitro-o-xylene was also increased to 71.1%:27.2%; both the conversions were over 96%.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.1123-40-6. In my other articles, you can also check out more blogs about 1123-40-6

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H6555N – PubChem

 

Related Products of 1123-40-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1123-40-6, Name is 4,4-Dimethylpiperidine-2,6-dione, molecular formula is C7H11NO2. In a Article£¬once mentioned of 1123-40-6

Enantioselective Copper-Catalyzed Intramolecular N?H Bond Insertion: Synthesis of Chiral 2-Carboxytetrahydroquinolines

The first highly enantioselective intramolecular N?H bond insertion was realized by using copper catalysts modified with chiral spirobisoxazoline ligands, which provides a novel strategy for the synthesis of chiral 2-carboxytetrahydroquinolines. This reaction features fast reaction rate, high yield, high enantioselectivity, and mild reaction conditions. (Figure presented.).

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Related Products of 1123-40-6, you can also check out more blogs about1123-40-6

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Piperidine – Wikipedia,
Piperidine | C5H6538N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1123-40-6,4,4-Dimethylpiperidine-2,6-dione,as a common compound, the synthetic route is as follows.

Crude 2- (2-METHOXY-5-NITRO-PHENOXY)-ETHANOL (0.43 g, 2 MMOL) was dissolved in dry THF, 4, 4-dimethylglutarimide (0.28 g, 2 mmol), triphenylphosphine (0.52 g, 2 MMOL) and diethylazodicarboxylate (1.1 ml, 2.4 MMOL) were added at 45 C. After 6 h the reaction mixture was concentrated in vacuo and purified by flash-chromatography (cyclohexane/ ethyl ether 3/7) to give 0.41 g of the title compound as a white solid. NMR (‘H, CECI3) : 8 7.88 (d, 1H), 7.73 (s, 1H), 6.85 (d, 1H), 4.30-4. 15 (m, 4H), 3.90 (s, 3H), 2.52 (s, 4H), 1.13 (s, 6H)., 1123-40-6

As the paragraph descriping shows that 1123-40-6 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/89897; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1123-40-6,4,4-Dimethylpiperidine-2,6-dione,as a common compound, the synthetic route is as follows.

Crude 2- (2-METHOXY-5-NITRO-PHENOXY)-ETHANOL (0.43 g, 2 MMOL) was dissolved in dry THF, 4, 4-dimethylglutarimide (0.28 g, 2 mmol), triphenylphosphine (0.52 g, 2 MMOL) and diethylazodicarboxylate (1.1 ml, 2.4 MMOL) were added at 45 C. After 6 h the reaction mixture was concentrated in vacuo and purified by flash-chromatography (cyclohexane/ ethyl ether 3/7) to give 0.41 g of the title compound as a white solid. NMR (‘H, CECI3) : 8 7.88 (d, 1H), 7.73 (s, 1H), 6.85 (d, 1H), 4.30-4. 15 (m, 4H), 3.90 (s, 3H), 2.52 (s, 4H), 1.13 (s, 6H)., 1123-40-6

As the paragraph descriping shows that 1123-40-6 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/89897; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

1123-40-6, 4,4-Dimethylpiperidine-2,6-dione is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A suspension of LiAlH4 (5.5 g, 145 mmol) in diethyl ether (300 ML) was treated in portions with 3,3-dimethylglutarimide (8.5 g, 57.7 mmol), heated to reflux, stirred overnight, cooled to room temperature, and treated with 1N NaOH (70 ML).The solution was decanted and the remaining solid was washed with diethyl ether (3*200 ML).The combined organic washes were washed with brine, dried (Na2SO4), filtered, and concentrated to a volume of 200 ML. The solution was treated with 2M HCl in diethyl ether (50 ML) and the mixture was filtered and the filter cake was washed with diethyl ether (3*150 ML) to provide the desired product (6.58 g, 76%). MS (CI) m/e 114 (M+H)+., 1123-40-6

As the paragraph descriping shows that 1123-40-6 is playing an increasingly important role.

Reference£º
Patent; Elmore, Steven W.; Park, Cheol-Min; Wang, Xilu; US2003/236247; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem