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The pyrolysis of aliphatic alpha-amino acids, glutamine, glutamic and aspartic acids, and formation of heterocyclic and polycyclic aromatic hydrocarbons (N-PACs and PAHs) were studied. Each amino acid was first pyrolyzed at 300 C to obtain a low-temperature tar (LTT) and a low-temperature char (LTC). The LTC was then pyrolyzed at 625 C to obtain the corresponding high-temperature tar (HTT) and high-temperature char (HTC). The tars were separately subjected, in some cases, to temperatures in the range 700-870 C to study secondary reactions. Oligomers of aspartic acid and glutamic acid were also pyrolyzed. The tars were analyzed by gas chromatography/mass spectrometry. Glutamic acid and glutamine underwent significant decomposition to volatile products at 300 C but aspartic acid required higher temperature. The heterocyclic compounds were primarily single-ring compounds comprised of five- or six-member heterocycles in the absence of secondary reactions, and up to four rings after the secondary pyrolysis. The PACs included nitriles from glutamine and glutamic acid and PAHs from aspartic acid. For aspartic acid, the results from oligomers were similar to those from the monomer, whereas the results from the glutamic acid oligomer were slightly different from glutamic acid. All three acids appeared to break down to smaller “building blocks” and then pyrosynthesize the N-PACs and PAHs.

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Piperidine – Wikipedia,
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Access to 1- and 2-azabicycloalkanes by intramolecular cyclization of allylsilanes on alpha-acyliminium ions is described.This methodology is also used to achieve a highly stereoselective total synthesis of (+/-)-mesembrine.

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Piperidine – Wikipedia,
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Aluminum trichloride promotes the nucleophilic ring-opening reaction of cyclic imides and oxazolidinones with amines.

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The 1,3,5-triazine ring is an extraordinary fragment that can take part in most types of intermolecular bonds. Microwave irradiation provides an efficient and green procedure for the selective preparation of s-triazines. Symmetrical and unsymmetrical 1,3,5-triazines have been obtained in good to excellent yields in short reaction times and under solvent free conditions. The structures have been determined by NMR-spectroscopy and X-ray crystallography. The optoelectronic and electrochemical properties have been investigated. The formation of complexes with Pd(II) and Ag(I), as well as the molecular recognition of glutarimide and riboflavin, demonstrate the extraordinary applications of these compounds.

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The present invention relates to succinimide and glutarimide derivatives, which can be used to treat a disease or disorder mediated through 1a and/or 1d adrenergic receptors. Compounds and pharmaceutical compositions disclosed herein can be used to treat benign prostatic hyperplasia (BPH) and related symptoms thereof. Further, such compounds can be used to treat lower urinary tract symptoms that may or may not be associated with BPH. The present invention also relates to processes to prepare the disclosed compounds, pharmaceutical compositions thereof, and methods of treating BPH or related symptoms thereof.

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The present invention provides a N – benzyl – N – aryl sulfonamide derivatives, the derivatives including its pharmaceutically acceptable salt and/or solvate. By substituted nitrobenzene with nitrogen-containing five-membered or […] heterocyclic (B ring) condensation, then the nitro also reduced to amino, and then through reductive amination, and tissue obtained; or substituted nitrobenzene is first nitro reduction, by reductive amination, and tissue, finally with the nitrogen-containing five-membered or […] heterocyclic (B ring) condensation to obtain. The invention experiments prove that, of the N – benzyl – N – aryl sulfonamide derivatives can be specifically combined and inhibit or reduce the potassium channel Kv1.3 activity, can be applied to humans or animals by Kv1.3 potassium channel abnormal activation of the autoimmune disease. The present invention provides inhibitors also includes the pharmaceutical composition of this compound. The derivatives of the general formula: (by machine translation)

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Piperidine – Wikipedia,
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In the reported experiments, poly(acrylic acid) and poly(methacrylic acid) homopolymers, copolymers, and 1- mu -thick films have been converted in high yield to their corresponding cyclic imide derivatives by an in situ gas-solid phase reaction at 200 degree C with ammonia, methylamine, and ethylamine, respectively. Under similar reaction conditions with H//2S or CH//3SH as the reactive gas, sulfur was incorporated into the polymers in low yield. Under UV and electron beam irradiation, these cyclic derivatives degraded with main chain scission to eliminate isocyanic acid or alkyl isocyanate and to form olefins and ketenes. Poly(diacrylimide) was the exception and crosslinked. The poor solubility in organic solvents and the very high solubility in aqueous solutions of base limited the use of these films as positive resists. However, poly(methyl methacrylate) copolymers, containing 20%-25% cyclic groups, exhibited adequate solubility and sensitivity to be utilized as lithographic resists.

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A compendium of phase change enthalpies published in 2010 is updated to include the period 1880-2015. Phase change enthalpies including fusion, vaporization, and sublimation enthalpies are included for organic, organometallic, and a few inorganic compounds. Part 1 of this compendium includes organic compounds from C1-C10. Part 2 of this compendium, to be published separately, will include organic and organometallic compounds from C11 to C192. Sufficient data are presently available to permit thermodynamic cycles to be constructed as an independent means of evaluating the reliability of the data. Temperature adjustments of phase change enthalpies from the temperature of measurement to the standard reference temperature, T = 298.15 K, and a protocol for doing so are briefly discussed.

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With an aim to provide means for developing a compound devoid of teratogenicity but retaining beneficial actions, a screening method for a non-teratogenic substance comprising bringing a test substance into contact with cereblon or a fragment of cereblon, evaluating the bindability of the test substance with cereblon or the fragment of cereblon, and selecting a test substance that does not bind to cereblon or the fragment of cereblon or a test substance exhibiting lower bindability with cereblon or the fragment of cereblon than does thalidomide is provided.

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Imidyl radicals, generated by photolysis of, or halogen-atom abstraction from, N-halogenoimides, are efficiently trapped by But2C=CH2 to give relatively persistent adducts which have been studied by e.s.r. spectroscopy.Bromine-atom abstraction from BrCH2CH2C(O)NCO (2) yields (1) which undergoes rapid 1,5-endo cyclisation to give the succinimidyl radical.This cyclisation has been investigated using e.s.r. spectroscopy in conjunction with spin-trapping by But2C=CH2 and ButN=O.The rate coefficient for cyclisation of (1) has been estimated to be 3.7 * 106 s-1 at 328 K in cyclohexane from analysis of the products from the radical-chain reaction between (2) and triethylgermane.E.s.r. and product-analysis studies show that (14) cyclises, more rapidly than (1), to give the 2,2-dimethylsuccinimidyl radical which subsequently undergoes ring opening to yield (15).The overall rearrangement of (14) to (15) represents a 1,2-shift of the -C(O)NCO group via an intermediate imidyl radical.The glutarimidyl radical is formed by 1,6-endo cyclisation of .It is proposed that the rapid cyclisation of omega-isocyanatoalkyl radicals provides strong evidence that the unpaired electron occupies a ?-orbital in the product imidyl radicals.

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