With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.111153-74-3,1-Phenylpiperidine-4-carbaldehyde,as a common compound, the synthetic route is as follows.
Step E 4-[2-{1-(Triphenylmethyl)-4-imidazolyl}ethenyl]-1-phenylpiperidine The product from Step D is dissolved in THF and cooled to -78 C. under nitrogen. A solution of LDA in THF is added dropwise. The reaction was stirred at -78 C. for 1 h, then a solution of 4-formyl-1-phenylpiperidine from Step A is added, and the reaction warmed to room temperature overnight. The reaction is quenched with ammonium chloride solution, and extracted with ethyl acetate. The title compound is obtained after chromatography on silica gel.
111153-74-3, 111153-74-3 1-Phenylpiperidine-4-carbaldehyde 13842992, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; Merck & Co., Inc.; US5891889; (1999); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem