Category: 1104083-27-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1104083-27-3,tert-Butyl 3-hydroxy-3-methylpiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Into a 250-mL round-bottomed flask, was placed tert-butyl 3-hydroxy-3- methylpiperidine-l-carboxylate (3 g, 13.9 mmol, 1 eq.), DCM (60 mL), pyridine (2.2 g, 0.03 mmol, 2 eq.). This was followed by the addition of a solution of 4-nitrophenyl carbonochloridate (8.4 g, 0.04 mmol, 3 eq.) in DCM (30 mL) dropwise with stirring at 0 C. The resulting solution was stirred for 3 days at rt. The reaction was then quenched by the addition of water (50 mL). The resulting mixture was washed with H2O (1 x 50 mL). The mixture was dried over anhydrous sodium sulfate and concentrated. The residue was applied onto a silica gel column with ethyl acetate :petroleum ether (10:90). This resulted in 2.5 g (47.16%) of tert-butyl 3-methyl-3-[[(4-nitrophenoxy)carbonyl]oxy]piperidine-l-carboxylate as a colorless oil.

1104083-27-3, As the paragraph descriping shows that 1104083-27-3 is playing an increasingly important role.

Reference：
Patent; PRINCIPIA BIOPHARMA INC.; LOU, Yan; OWENS, Timothy Duncan; BRAMELD, Kenneth Albert; GOLDSTEIN, David Michael; (302 pag.)WO2019/99582; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1104083-27-3, tert-Butyl 3-hydroxy-3-methylpiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tert-butyl 3-hydroxy-3-methylpiperidine-i-carboxylate (0.10 g, 0.46 mmol)in dry DMF (1 mL) under argon atmosphere was added sodium hydride (60% suspension, 0.027 g, 0.69 mmol, 1.5 equiv) at 0 C. The reaction was warmed to room temperature and stirred for 10 mm; 3-(trifluoromethyl)-i-fluorobenzene (0.084 g, 0.511 mmol, 1.1 equiv) was added at 0 C. The reaction mixture was heated at 100 C in sealed tube for 16 h. After completion, the reaction was diluted with water and extracted with ethyl acetate. The organicextract was dried over sodium sulfate, filtered and concentrated under reduced pressure.Purification using silica gel column chromatography (20% EtOAc Hexanes as eluent) toafford 0.065 g of tert-butyl 3-methyl-3-(3-(trifluoromethyl)phenoxy)piperidine- 1-carboxylate(Yield = 39%)., 1104083-27-3

1104083-27-3 tert-Butyl 3-hydroxy-3-methylpiperidine-1-carboxylate 57416953, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; THE BROAD INSTITUTE, INC.; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; HOLSON, Edward; WAGNER, Florence, Fevrier; WEIWER, Michel; SCOLNICK, Edward; PALMER, Michelle; DORDEVIC, Luka; LEWIS, Michael; PAN, Jennifer, Q.; ZHANG, Yan-Ling; XU, Qihong; (425 pag.)WO2016/100940; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1104083-27-3,tert-Butyl 3-hydroxy-3-methylpiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of tert-butyl 3-hydroxy-3-methylpiperidine-1-carboxylate (0.3 g, 1.39 mmol) in MeOH (5 mL) was added 4.0 M HC1 in Dioxane (1.73 mL) at 0 C. The reaction mixture was stirred at room temperature for 4 h. After completion, volatiles were removed under reduced pressure to afford 0.15 g of 3 -methylpiperidin-3 -ol hydrochloride (Yield = 71%)., 1104083-27-3

The synthetic route of 1104083-27-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; THE BROAD INSTITUTE, INC.; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; HOLSON, Edward; WAGNER, Florence, Fevrier; WEIWER, Michel; SCOLNICK, Edward; PALMER, Michelle; DORDEVIC, Luka; LEWIS, Michael; PAN, Jennifer, Q.; ZHANG, Yan-Ling; XU, Qihong; (425 pag.)WO2016/100940; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem