Category: 106243-23-6

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， COA of Formula: C8H13N3, Which mentioned a new discovery about 106243-23-6

Starting from the structure of thioperamide, a known H3-antagonist, a new series of compounds with a benzothiazole nucleus instead of the cyclohexylcarbothioamide moiety was synthesized. Various substituents, selected by experimental design, were introduced in position 6 of the benzothiazole nucleus, in order to change its physico-chemical characteristics. The lipophilicity of the synthesized compounds was measured by means of RP-HPLC, and their H3-receptor affinity was evaluated by competitive binding assays on rat cortex synaptosomes, with the labelled ligand N(alpha)-[3H]methylhistamine. A QSAR analysis was performed on the experimental data, using also substituent constants taken from the literature. The newly synthesized compounds showed lower H3-affinities than thioperamide; quantitative structure-activity relationships, described by models obtained with PLS and MRA techniques, were observed among benzothiazole derivatives. According to these relationships, any attempt to improve the potency of these compounds should involve the substitution of the benzothiazole moiety with less bulky and/or more flexible structures, which should also be less lipophilic and allow better electronic interactions with the binding site. 1-(Benzothiazol-2-yl)-4-[(1H)-imidazol-4-yl]piperidine represents a limit structure for H3-activity, since it seems impossible to improve its affinity by means of substitution in the studied position of the benzothiazole nucleus, as shown by predictions performed by a PLS model.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 106243-23-6, help many people in the next few years.COA of Formula: C8H13N3

Reference：
Piperidine – Wikipedia,
Piperidine | C5H8348N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ name: 4-(1H-imdazol-4-yl)piperidine, Which mentioned a new discovery about 106243-23-6

IMIDAZOYLALKYL SUBSTITUTED WITH A SIX MEMBERED NITROGEN CONTAINING HETEROCYCLIC RING

Disclosed is a compound of Formula 1.0: STR1 or a pharmaceutically acceptable salt or solvate thereof. Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier and an effective amount of a Compound of Formula 1.0.

< P> Further disclosed is a method of treating allergy (for example asthma), inflammation, hypertension, raised intraocular pressure (such as glaucoma)–i.e., a method of lowering intraocular pressure, sleeping disorders, states of hyper and hypo motility and acidic secretion of the gastrointestinal tract, hypo and hyperactivity of the central nervous system (for example, agitation and depression) and other CNS disorders (such as Alzheimers, Schizophrenia, and migraine) comprising administering an effective amount of a compound of Formula 1.0 to a patient in need of such treatment.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 106243-23-6, help many people in the next few years.name: 4-(1H-imdazol-4-yl)piperidine

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H8354N – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 106243-23-6, name is 4-(1H-imdazol-4-yl)piperidine, introducing its new discovery. Computed Properties of C8H13N3

PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY

A compound which is a piperidine derivative of formula (I) STR1 in which R represents hydrogen, or unbranched or branched C 1-C 6 alkyl group; and

Ar represents phenyl optionally substituted with one or more radicals selected from the halogens, amino, C 1-C 2 alkoxy and (C 3-C 6) cycloalkyl(C 1-C 2) alkoxy, or a heteroaryl group;

< P>or a pharmaceutically acceptable acid addition salt thereof;

provided that when R is hydrogen Ar is not phenyl or 4-chlorophenyl.

The compounds are useful in therapy as ligands for 5-HT 3 and 5-HT. sub.4 receptors.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 106243-23-6 is helpful to your research. Computed Properties of C8H13N3

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H8359N – PubChem

 

106243-23-6, 4-(1H-imdazol-4-yl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,106243-23-6

EXAMPLE 1 4-(1-CYCLOHEXYLAMINOTHIOCARBONYL-4-PIPERIDYL)-1H-IMIDAZOLE 1.4 g (0.0092 mole) of 4-(4-piperidyl)-1H-imidazole and 1.42 g (0.010 mole) of cyclohexyl isothiocyanate are brought to reflux for 2 hours in 100 cm3 of anhydrous toluene. Precipitate formed on cooling is drained, washed with anhydrous ethyl ether, dried and recrystallized in toluene. White powder, M.p. (d.) 170 C., w=2 g. 74% yield. IR spectrum (KBr): 3240 (NH). Principal bands: 2920, 2840, 1520, 1440, 1350, 1330, 1250, 1175, 1090, 970, 830, 755 and 695 cm-1. NMR spectrum: DMSO-d6 deltaH, imidazole: 7.45 and 6.66. coupling constant JH2-H5 =0.90 Hz. deltaNH: 7.13 and 7.05 ppm. deltaH piperidine and cyclohexyl: 4.61, 4.16, 2.98, 1.76 and 1.20 ppm.

As the paragraph descriping shows that 106243-23-6 is playing an increasingly important role.

Reference£º
Patent; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Caen; Societe Civile Bioprojet; US4707487; (1987); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem