Category: 106-52-5

Synthetic Route of 106-52-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 106-52-5, Name is 1-Methylpiperidin-4-ol, SMILES is OC1CCN(C)CC1, belongs to piperidines compound. In a article, author is Hadiyal, S. D., introduce new discover of the category.

Microwave-Assisted Three-Component Domino Synthesis of Polysubstituted 4H-Pyran Derivatives and Their Anticancer Activity

An efficient microwave-assisted one-pot procedure has been proposed for the synthesis of new 4-aryl-6-(methylamino)-5-nitro-2-(1H-pyrrol-2-yl)-4H-pyran-3-carbonitriles by condensation of 3-oxo-3-(1H-pyrrol-2-yl)propanenitrile with (E)-N-methyl-1-(methylsulfanyl)-2-nitroethenamine and substituted benzaldehydes in the presence of a catalytic amount of piperidine using ethanol as a solvent. The transformation occurs via successive Knoevenagel condensation, Michael addition, and intramolecular cyclization. The proposed procedure is advantageous due to its one-pot mode, short reaction time, simple purification by recrystallization, and excellent yields. The product structure was confirmed using various spectroscopic techniques, including IR,H-1 and C-13 NMR, LC/MS, elemental analysis, and single crystal X-ray diffraction study. The synthesized compounds were evaluated for their anticancer activity against 60 different human cancer cell lines in nine cancer panels, and two compounds were found to be potent against different cell lines.

Synthetic Route of 106-52-5, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 106-52-5.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 106-52-5, Name is 1-Methylpiperidin-4-ol, SMILES is OC1CCN(C)CC1, belongs to piperidines compound. In a document, author is Lazewska, Dorota, introduce the new discover, Recommanded Product: 1-Methylpiperidin-4-ol.

Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H-3 Receptor Antagonists and Monoamine Oxidase B Inhibitors

Dual target ligands are a promising concept for the treatment of Parkinson’s disease (PD). A combination of monoamine oxidase B (MAO B) inhibition with histamine H-3 receptor (H3R) antagonism could have positive effects on dopamine regulation. Thus, a series of twenty-seven 4-tert-butylphenoxyalkoxyamines were designed as potential dual-target ligands for PD based on the structure of 1-(3-(4-tert-butylphenoxy)propyl)piperidine (DL76). Probed modifications included the introduction of different cyclic amines and elongation of the alkyl chain. Synthesized compounds were investigated for human H3R (hH(3)R) affinity and human MAO B (hMAO B) inhibitory activity. Most compounds showed good hH(3)R affinities with K-i values below 400 nM, and some of them showed potent inhibitory activity for hMAO B with IC50 values below 50 nM. However, the most balanced activity against both biological targets showed DL76 (hH(3)R: K-i = 38 nM and hMAO B: IC50 = 48 nM). Thus, DL76 was chosen for further studies, revealing the nontoxic nature of DL76 in HEK293 and neuroblastoma SH-SY5Ycells. However, no neuroprotective effect was observed for DL76 in hydrogen peroxide-treated neuroblastoma SH-SY5Y cells. Furthermore, in vivo studies showed antiparkinsonian activity of DL76 in haloperidol-induced catalepsy (Cross Leg Position Test) at a dose of 50 mg/kg body weight.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 106-52-5 is helpful to your research. Recommanded Product: 1-Methylpiperidin-4-ol.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 106-52-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 106-52-5, Name is 1-Methylpiperidin-4-ol, SMILES is OC1CCN(C)CC1, belongs to piperidines compound. In a article, author is Liu, Juan, introduce new discover of the category.

Molecular insights into the hydrodenitrogenation mechanism of pyridine over Pt/gamma-Al2O3 catalysts

The hydrodenitrogenation of nitrogen-containing heterocycles over noble metals has fundamental importance for energy and environmental science. To develop more efficient catalyst, mechanistic investigation has been conducted with a method combining in situ Fourier transformation infrared experiments and density functional theory calculations in this work. The in situ experiments indicate flatly adsorbed pyridine molecules convert to pyridinium and alpha-pyridyl species at higher temperature on metallic Pt of Pt/gamma-Al2O3 catalysts. Pyridine hydrogenation distinctly takes place at 150 degrees C with the appearance of methylene stretching vibrations, and a stepwise mechanism is identified as the temperature further increases. The adsorption, hydrogenation and hydrogenolysis of pyridine on Pt are studied in detail by theoretical calculations. In line with these findings, the geometry optimization confirms pyridine preferentially adsorbs on Pt(111) and Pt(211) both in a parallel configuration. Based on the Langmuir-Hinshelwood mechanism, the results show successive hydrogenation markedly lowers the energy barrier for subsequent hydrogenolysis. The C-N bond cleavage occurs via nucleophilic attack of pentahydropyridine, rather than piperidine, which determines the reaction products, including piperidine, n-pentylamine and n-pentane. The comparative study reveals both hydrogenation and hydrogenolysis are kinetically and thermodynamically more competitive on Pt(211) than Pt(111). Especially for hydrogenolysis, the coordinatively unsaturated Pt step atoms play an essential role in C-N bond cleavage. Thus, hydrogenolysis is more geometric-dependent than hydrogenation. This provides instructive information for the design of catalysts with adjustable product selectivity.

Synthetic Route of 106-52-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 106-52-5 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is an experimental science, Product Details of 106-52-5, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 106-52-5, Name is 1-Methylpiperidin-4-ol, molecular formula is C6H13NO, belongs to piperidines compound. In a document, author is Fagge, Ibrahim I..

Kinetics and mechanism of counterionic salt-catalysed piperidinolysis of anionic phenyl salicylate in the presence of cationic-nonionic mixed micelles

The quantitative correlation of counterion-affinity to aqueous hexadecyltrimethylammonium bromide (HDAB, cationic micelles/nanoparticles) and the counterion-induced HDAB micellar growth, in the presence of different amounts of poly(ethylene glycol hexadecyl ether) (C16E20, nonionic surfactant), was achieved by the use of a semi-empirical kinetic (SEK) method. The values of the ratio of cationic HDAB, as well as mixed HDAB-C16E20, micellar binding constants of X and Br, K-X/K-Br (= K-X(Br) or R-X(Br)) for X = 4-ClC6H4CO2-, were obtained by the SEK method. The concentration range (0.006-0.015 M) of pure HDAB was found to have no influence on the values of K-X(Br) or R-X(Br). These observations were also recorded upon addition of a nonionic surfactant, C16E20, in an aqueous solution of HDAB. The mean value of K-X(Br) or R-X(Br) obtained in the presence of pure HDAB (K-X(Br) or R-X(Br) = 50.3) is 2.3 times larger than that in the presence of mixed HDAB-C16E20 (K-m(X)Br or R-m(X)Br = 21.7). From rheometric measurements of aqueous HDA(+)/4-ClC6H4CO2- with 0.015 M HDAB, single symmetric maxima (at both 25 and 35 degrees C) were obtained at [4-ClC6H4CO2Na] = 0.03 M. This is evidence for the existence of wormlike micelles/nanoparticles. However, the absence of a maximum in rheometric data for aqueous HDA(+)/C16E20/4-ClC6H4CO2- with 0.015 M HDAB and 0.006 M C16E20 at various [4-ClC6H4CO2Na] revealed the existence of spherical micelles.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 106-52-5, in my other articles. Product Details of 106-52-5.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 106-52-5, Name is 1-Methylpiperidin-4-ol, molecular formula is C6H13NO, belongs to piperidines compound. In a document, author is Nairoukh, Zackaria, introduce the new discover, Quality Control of 1-Methylpiperidin-4-ol.

Understanding the Conformational Behavior of Fluorinated Piperidines: The Origin of the Axial-F Preference

Gaining an understanding of the conformational behavior of fluorinated compounds would allow for expansion of the current molecular design toolbox. In order to facilitate drug discovery efforts, a systematic survey of a series of diversely substituted and protected fluorinated piperidine derivatives has been carried out using NMR spectroscopy. Computational investigations reveal that, in addition to established delocalization forces such as charge-dipole interactions and hyperconjugation, solvation and solvent polarity play a major role. This work codifies a new design principle for conformationally rigid molecular scaffolds.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 106-52-5. Quality Control of 1-Methylpiperidin-4-ol.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 106-52-5, Name is 1-Methylpiperidin-4-ol, molecular formula is C6H13NO, belongs to piperidines compound. In a document, author is Prabhu, Gurpur Rakesh D., introduce the new discover, Recommanded Product: 1-Methylpiperidin-4-ol.

Sample Flow Rate Scan in Electrospray Ionization Mass Spectrometry Reveals Alterations in Protein Charge State Distribution

Sample flow rate is one of the parameters that influence the sensitivity of electrospray ionization (ESI) mass spectrometry. By varying the sample flow rate, initial droplets of different sizes can be generated. Protein molecules in small droplets may form gas-phase ions earlier than the ones in large droplets. Here, we have systematically studied the influence of sample flow rate on the ESI charge state distributions (CSDs) of model proteins. A dedicated programmable sample flow rate scanner was used to infuse protein samples at different flow rates into a mass spectrometer. The synergistic influence of sample flow rate and various electrolytes (ammonium acetate, ammonium bicarbonate, ammonium formate, and piperidine) was studied. Significant alterations to the CSDs with increasing flow rate were observed. For example, in the presence of ammonium acetate, at low flow rates, lower charge states of proteins showed high intensities, while at high flow rates, ions related to higher charge states of proteins dominated the spectra. On the other hand, in the presence of piperidine, a significant reduction in the ion currents of all charge states was observed during the flow rate scan. Our observations suggest that at low flow rates the protein molecules follow a charged residue model of ionization mechanism, and at high flow rates-due to structural changes in protein molecules in large ESI droplets-the charged residue and chain ejection models can possibly coexist. We propose the use of sample flow rate scan as a way to reveal the influence of flow rate on the CSDs of the studied proteins.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 106-52-5. Recommanded Product: 1-Methylpiperidin-4-ol.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Category: piperidines, 106-52-5, Name is 1-Methylpiperidin-4-ol, molecular formula is C6H13NO, belongs to piperidines compound. In a document, author is Bucknell, Sarah J., introduce the new discover.

Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2 ‘-oxo-1 ‘,2 ‘-dihydrospiro[piperidine-4,4 ‘-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine

Structure-based drug design enabled the discovery of 8, HTL22562, a calcitonin gene-related peptide (CGRP) receptor antagonist. The structure of 8 complexed with the CGRP receptor was determined at a 1.6 angstrom resolution. Compound 8 is a highly potent, selective, metabolically stable, and soluble compound suitable for a range of administration routes that have the potential to provide rapid systemic exposures with resultant high levels of receptor coverage (e.g., subcutaneous). The low lipophilicity coupled with a low anticipated clinically efficacious plasma exposure for migraine also suggests a reduced potential for hepatotoxicity. These properties have led to 8 being selected as a clinical candidate for acute treatment of migraine.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 106-52-5. Category: piperidines.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Kondej, Magda, once mentioned the application of 106-52-5, Name is 1-Methylpiperidin-4-ol, molecular formula is C6H13NO, molecular weight is 115.17, MDL number is MFCD00006500, category is piperidines. Now introduce a scientific discovery about this category, Quality Control of 1-Methylpiperidin-4-ol.

Synthesis, Structural and Thermal Studies of 3-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-ethoxy-1H-indole (D2AAK1_3) as Dopamine D-2 Receptor Ligand

Compound D2AAK1_3 was designed as a modification of the lead structure D2AAK1 (an in vivo active multi-target compound with nanomolar affinity to a number of aminergic GPCRs) and synthesized in the reaction of 5-ethoxyindole and 1-benzyl-4-piperidone. This compound has an affinity to the human dopamine D-2 receptor with K-i of 151 nM. The aim of these studies was the structural and thermal characterization of the compound D2AAK1_3. In particular; X-ray studies; molecular docking and molecular dynamics as well as thermal analysis were performed. The studied compound crystallizes in orthorhombic system; in chiral space group P2(1)2(1)2(1). The compound has a non-planar conformation. The studied compound was docked to the novel X-ray structure of the human dopamine D-2 receptor in the inactive state (PDB ID: 6CM4) and established the main contact between its protonatable nitrogen atom and Asp (3.32) of the receptor. The obtained binding pose was stable in molecular dynamics simulations. Thermal stability of the compound was investigated using the TG-DSC technique in the air atmosphere, while TG-FTIR analyses in air and nitrogen atmospheres were also performed. The studied compound is characterized by good thermal stability. The main volatile products of combustion are the following gases: CO2; H2O toluene and CO while in the case of pyrolysis process in the FTIR spectra; the characteristic bands of NH3; piperidine and indole are additionally observed.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 106-52-5, Quality Control of 1-Methylpiperidin-4-ol.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: 1-Methylpiperidin-4-ol, 106-52-5, Name is 1-Methylpiperidin-4-ol, SMILES is OC1CCN(C)CC1, belongs to piperidines compound. In a document, author is Singh, V. D., introduce the new discover.

Synthesis, FT-IR, UV-VIS, DFT studies and SCXRD structure of 1-(tert-butyl) 3-ethyl-3-(hydroxy(thiophen-2-yl)methyl)piperidine-1,3-dicarboxylate

The crystal structure of 1-(tert-butyl) 3-ethyl 3-(hydroxy(thiophen-2-yl)methyl)piperidine-1,3-dicarboxylate (C18H25NO5S) I has been determined by Single Crystal X-ray Diffraction (SCXRD) techniques. It crystallizes in the orthorhombic space group Pca2(1) with unit cell parameters a = 19.4502(13)angstrom, b= 6.3571(4)angstrom, c= 15.2577(10)angstrom and number of molecules per unit cell, Z = 4. The intensity data have been collected at room temperature (293 K) and the structure has been solved by direct methods. The full matrix least-squares refinement has converged the final R-value to 0.035 for 2251 observed reflections. The piperidine ring adopts a chair conformation. The structure is stabilized by two C-H center dot center dot center dot O (intermolecular interactions) and five C-H center dot center dot center dot O (intramolecular interactions). The structural and spectral studies of 1-(tert-butyl) 3-ethyl 3-(hydroxy(thiophen-2-yl)methyl)piperidine-1,3-dicarboxylate have been carried out by using both experimental and quantum chemical techniques.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 106-52-5. Recommanded Product: 1-Methylpiperidin-4-ol.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Electric Literature of 106-52-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.106-52-5, Name is 1-Methylpiperidin-4-ol, molecular formula is C6H13NO. In a Article£¬once mentioned of 106-52-5

Selective alkylation of a 6,7-dihydroxyquinazoline

A convenient 3-step multi-parallel process for the preparation of 4-(3-chloro-2-fluoroanilino)-6,7-bisalkoxyquinazolines is highlighted.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 106-52-5

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H2635N – PubChem