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The present invention encompasses compounds of general formula (1) wherein R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H2364N – PubChem

 

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On the basis of qualitative structure-activity relationships developed in the preceding article, a series of 32 new mitomycin A analogues were prepared and tested in antitumor screens. Seven of them gave greater prolongation of life (ILS) than mitomycin C in the mouse P388 leukemia assay. They included examples with 7-O substituents such as cyclic ethers and nitrogen heterocycles. A Hansch analysis was attempted with log P and MR as the independent variables, but no statistically significant correlation could be made. Seven compounds, chosen mainly for their good potency (MED), were tested in the subcutaneous B16 melanoma assay in mice and four of them showed greater ILS than mitomycin C.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H2486N – PubChem

 

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, category: piperidines, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 106-52-5, Name is 1-Methylpiperidin-4-ol, molecular formula is C6H13NO. In a Patent, authors is ,once mentioned of 106-52-5

A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.

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The present invention concerns novel compounds, their preparation and their uses, therapeutic uses in particular. More specifically it concerns derivative compounds having at least two aromatic cycles, their preparation and their uses, in particular in the area of human or animal health. These compounds have an affinity for the biological receptors of neuropeptide Y, NPY, present in the central and peripheral nervous systems. The compounds of the invention are preferably NPY antagonists, and more particularly antagonists of sub-type NPY Y1, and can therefore be used for the therapeutic or prophylactic treatment of any disorder involving NPY. The present invention also concerns pharmaceutical compositions containing said compounds, their preparation and their uses, as well as treatment methods using said compounds.

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Related Products of 106-52-5, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.106-52-5, Name is 1-Methylpiperidin-4-ol, molecular formula is C6H13NO. In a article,once mentioned of 106-52-5

Compounds of formula (I), in salt or zwitterionic form, wherein J, L, M, R1, R2, R3, R4 and R 5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H2570N – PubChem

 

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The work reports a comparative study on the pyrolysis of five agricultural crop residues (peanut straw, cotton straw, sorghum stalk, corn stalk and reed) using a gas-sweeping fixed bed reactor. The study aims at clarifying the role played by the neutral extractives and inherent active minerals in the pyrolysis characteristics, product distributions and bio-oil compositions. Among five crop residues, reed showed the highest bio-oil yield but with the highest oxygen content and the lowest HHV (higher heat value), in relation to the least alkali and alkaline earth metals (AAEMs) in it. Peanut straw had a content of neutral extractives as high as 47.4%, which contributed to the formations of a significantly higher proportion of long chain aliphatic hydrocarbons and liquid nitrogenous compounds, distinct from four other crop residues. Peanut straw was also highly enriched with AAEMs, which was responsible for a strong catalytic activity for the selective deoxygenation of bio-oil. Neutral extractives in sorghum stalk and corn stalk formed some long chain fatty oxygenates and less nitrogenous compounds. The bio-oils derived from these two biomasses contained oxygenates as dominant compounds, however, they had a lower fraction of heavy constituents, lower oxygen contents, and higher HHVs than those of reed and cotton straw. This result was attributed to the catalyzed bio-oil deoxygenation by the relatively abundant AAEMs in sorghum stalk and corn stalk.

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Reference:
Piperidine – Wikipedia,
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The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel heterocyclic compounds, or a stereoisomer or pharmaceutically acceptable salt, solvate, or prodrug form thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H2332N – PubChem

 

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Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. Recommanded Product: 106-52-5

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The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

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Piperidine – Wikipedia,
Piperidine | C5H2310N – PubChem

 

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The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 106-52-5 is helpful to your research. Recommanded Product: 106-52-5

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The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

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Reference:
Piperidine – Wikipedia,
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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 106-52-5, molcular formula is C6H13NO, introducing its new discovery. Application In Synthesis of 1-Methylpiperidin-4-ol

A new series of silicon(IV) phthalocyanines (SiPcs) axially di-substituted with piperidinyl moieties (compounds 1, 2a, and 3a) and their N-methylated derivatives (compounds 2b and 3b) have been synthesized and characterized. Meanwhile, an analogue di-substituted with cyclohexyl groups (compound 4) has also been prepared as a control. The antifungal photoactivities of these SiPcs toward Candida albicans were found to follow the order: 2b > 3a ? 3b > 1 ? 2a > 4. The structure-activity relationship of these phthalocyanines has been discussed by investigating their photophysical and photochemical properties, partition coefficient, and cellular uptake. The cationic phthalocyanine 2b shows the highest photodynamic activity against C. albicans causing 4 log10 reduction of this fungus at 100 muM, which could be attributed to its high singlet oxygen yields, less aggregation in aqueous media, and relatively efficient cellular uptake.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H2628N – PubChem