Sep 2021 News Extended knowledge of 10465-81-3

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The invention is directed to 4h-benzo[1,4]oxazin-3-ones useful as peroxisome proliferator activated receptor gamma (PPARgamma) agonists or antagonists. Pharmaceutical compositions comprising compounds of the present invention and methods of treating conditions such as NIDDM and obesity are also disclosed.

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Compositions useful in methods of treating humans and animals infected with viruses of the retrovirus group contain azoic compounds of the general formula STR1 wherein R1, R2, R3 and R4 are indentical or different and each represents an atom of hydrogen or an aliphatic or aromatic hydrocarbon radical comprising from 1 to 6 carbon atoms, R1 and R2 may be bonded together to form a heterocyclic ring with their adjacent nitrogen atom, and R3 and R4 may be bonded together to form a heterocyclic ring with their adjacent nitrogen atom; X1 and X2 are indentical or different and each represents an oxygen atom or an NR5 group, wherein R5 is a hydrogen atom, an aliphatic or aromatic hydrocarbon radical comprising from 1 to 6 carbon atoms, or a nitro group; and wherein when two NR5 groups are simultaneously present each R5 may be indentical to or different from the other.

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Compounds of formula (I) in which all variables are defined in the description and their salts inhibit the enzyme oxido squalene cyclase and are useful in treating hypercholesterolemia and also as anti-fungal agents. Processes for their preparation are also described together with their use in medicine.

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An objective of the present invention is to provide compounds having integrin alphavbeta3 antagonistic activity, cell adhesion inhibitory activity, GP IIb/IIIa antagonistic activity, and/or human platelet aggregation inhibitory activity, and, therapeutic agents for treating cardiovascular diseases, angiogenesis-related diseases, cerebrovascular diseases and the like and for inhibiting platelet aggregation. The derivatives according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: wherein A represents a five- to seven-membered heterocyclic group containing two nitrogen atoms or the like; D represents >NH2, >CH2 or the like; X and Z represent CH or a nitrogen atom; R7 and R8 represent alkyl, halogen or the like; Q represents >C=O, >CH2 or the like; R9 represents H, alkyl, aralkyl or the like; R10 represents H, alkynyl or the like; R11 represents H, substituted amino or the like; R12 represents H or alkyl; m is 0 to 5; n is 0 to 4; p and q are each 1 to 3; and r is 0 or 1.

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The present invention provides PAR4 agonist peptides. These peptides are useful for developing robust PAR4 receptor assays.

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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 10465-81-3, molcular formula is C12H20N4O2, introducing its new discovery. Safety of Diazene-1,2-diylbis(piperidin-1-ylmethanone)

A neurotrophin production/secretion promoting agent which comprises an azole derivative of the formula: wherein R1 represents a halogen atom, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, a thiol group which may optionally be substituted, or an amino group which may optionally be substituted; A represents an acyl group which may optionally be substituted, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, or a carboxyl group which may optionally be esterified or amidated; B represents an aromatic group which may optionally be substituted; X represents oxygen atom, sulfur atom, or nitrogen atom which may optionally be substituted; and Y represents a divalent hydrocarbon group or heterocyclic group, or a salt thereof; which is useful as an agent for preventing or treating neuropathy.

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The present disclosure relates to bifunctional compounds, which find utility as modulators of tau protein. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a VHL or cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds tau protein, such that tau protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of tau. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of tau protein. Diseases or disorders that result from aggregation or accumulation of tau protein are treated or prevented with compounds and compositions of the present disclosure.

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Novel thiazolidinedione, oxazolidinedione and oxadiazolidinedione derivatives, process for their manufacture, pharmaceutical preparations containing them and the use of the compounds in conditions associated with insulin resistance.

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The present invention provides a compound comprising a repeating unit of formula (I)???in which:Arepresents a nitrogen atom, a carbon atom, a group -CR1- or an aromatic or alicyclic group, wherein R1represents a hydrogen atom or lower alkyl,Mrepresents a repeating monomer unit;n1to n3each independently represent 0 or an integer having a value of from 1 to 3, with the proviso that 1 < n1+ n2+ n3< 4;P1, P2, P3each independently represent a photoactive group; andB1to B4each independently represent a residue of general formula IIas well as photoactive polymers prepared from such compounds and the use of such compounds in the preparation of liquid crystal orientation layers and structured and unstructured electro-optical elements. Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: Diazene-1,2-diylbis(piperidin-1-ylmethanone), If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 10465-81-3, in my other articles.

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In an article, author is Zhu, Chen, once mentioned the application of 10465-81-3, Name is Diazene-1,2-diylbis(piperidin-1-ylmethanone), molecular formula is C12H20N4O2, molecular weight is 252.3128, MDL number is MFCD00010111, category is piperidines. Now introduce a scientific discovery about this category, Formula: C12H20N4O2.

Discovery of aryl-piperidine derivatives as potential antipsychotic agents using molecular hybridization strategy

Schizophrenia is a chronic, disabling mental disorder that affects about one percent of world’s population. Drugs acting on multiple targets have been demonstrated to provide superior efficacy in schizophrenia than agents acting on single target. In this study, based on FW01, a selective potent 5-HT1A receptor agonist discovered via dynamic pharmacophore-based virtual screening, molecular hybridization strategy was employed to optimize its in vitro activity over D-2 and 5-HT2A receptors. The optimized compound 9f was found to show dual potent D-2 and 5-HT2A receptors antagonistic activity. In addition, compound 9f showed good in vivo metabolic stability with t(1/2) of 2 h in ICR mice and good capability to penetrate the blood-brain barrier with (K)p value of 4.03. These results demonstrated that the dual D-2 and 5-HT1A receptor antagonist 9f could serve as a promising lead compound to discover potent antipsychotic agents. (c) 2020 Elsevier Masson SAS. All rights reserved.

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