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In an article, author is Zhu, Chen, once mentioned the application of 10465-81-3, Name is Diazene-1,2-diylbis(piperidin-1-ylmethanone), molecular formula is C12H20N4O2, molecular weight is 252.3128, MDL number is MFCD00010111, category is piperidines. Now introduce a scientific discovery about this category, Formula: C12H20N4O2.
Discovery of aryl-piperidine derivatives as potential antipsychotic agents using molecular hybridization strategy
Schizophrenia is a chronic, disabling mental disorder that affects about one percent of world’s population. Drugs acting on multiple targets have been demonstrated to provide superior efficacy in schizophrenia than agents acting on single target. In this study, based on FW01, a selective potent 5-HT1A receptor agonist discovered via dynamic pharmacophore-based virtual screening, molecular hybridization strategy was employed to optimize its in vitro activity over D-2 and 5-HT2A receptors. The optimized compound 9f was found to show dual potent D-2 and 5-HT2A receptors antagonistic activity. In addition, compound 9f showed good in vivo metabolic stability with t(1/2) of 2 h in ICR mice and good capability to penetrate the blood-brain barrier with (K)p value of 4.03. These results demonstrated that the dual D-2 and 5-HT1A receptor antagonist 9f could serve as a promising lead compound to discover potent antipsychotic agents. (c) 2020 Elsevier Masson SAS. All rights reserved.
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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem