With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.104-58-5,3-(Piperidin-1-yl)propan-1-ol,as a common compound, the synthetic route is as follows.
General procedure: Sodium (1.2 mmol) was added to a solution of an alcohol (1.0 mmol) in dry THF and the mixture was stirred at rt for 1 h. 4-Chloroquinazoline [22] (6, 1.0 mmol) was then added, and the resultant solution was stirred at rt for 24 h. The mixture was diluted with ethyl acetate (10 mL), washed with brine (10 mL) and dried over sodium sulfate. The products were purified by column chromatography (hexane-ethyl acetate 8:2).
104-58-5, As the paragraph descriping shows that 104-58-5 is playing an increasingly important role.
Reference£º
Article; ?pulak, Marcel; Pourova, Jana; Vopr?alova, Marie; Miku?ek, Ji?i; Kune?, Ji?i; Vacek, Jan; Ghavre, Mukund; Gathergood, Nicholas; Pour, Milan; European Journal of Medicinal Chemistry; vol. 74; (2014); p. 65 – 72;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem