Category: 10338-57-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

(Z)-(4-(isobenzofuran-1(3H)-ylidenemethyl)phenyl)methanol(5) (190.6 mg, 0.8 mmol), 4-(piperidin-1-yl)benzaldehyde (6)(227.2 mg, 1.2 mmol), t-BuOK (0.48 mmol, 1 M in THF) and 18-crown-6 (190.4 mg, 0.72 mmol) in DMF (4 mL) were stirred at110 C under nitrogen atmosphere for 3 h. The mixture was cooledand saturated NH4Cl (aq) was added to quench the reaction. Theresulting mixture was extracted with CH2Cl2 and the organic phasewas washed with brine, dried over Na2SO4. The solvent was evaporatedand the residue was passed through column chromatography on silica gel (eluent: PE/EtOAc 10:1, v/v) toafford the crude product (4-((Z)-((Z)-3-(4-(piperidin-1-yl)benzylidene)isobenzofuran-1(3H)-ylidene)-methyl)phenyl)methanol 7(282.0 mg, 86%) without further purification [49].

10338-57-5, As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Shang, Xue Song; Li, Nian Tai; Guo, Zhi Qian; Liu, Pei Nian; Dyes and Pigments; vol. 132; (2016); p. 167 – 176;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of NaH (146mg, 6.08mmol) in THF (2mL) was added a solution of intermediate 11 (500mg, 1.52mmol) in THF (4mL) at 0C, and the mixture was stirred for 40min under argon. And a solution of corresponding substituted benzaldehydes (2-1b-m, 1.52mmol) in THF (1mL) was added dropwise. Then the mixture was stirred for another 4-7h under argon. After the reaction was completed, the mixture was quenched with 3mol/L HCl and basified with saturated aqueous solution of Na2CO3. Then the mixture was extracted with ethyl acetate (15mL×3) and the combined organic phases were washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to provide crude product, the crude product was purified on silica chromatography to afford corresponding target compounds 12b-m.

10338-57-5, As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Cao, Zhongcheng; Deng, Yong; Li, Wei; Shi, Yichun; Song, Qing; Yang, Xia; Zhang, Li; Bioorganic Chemistry; vol. 97; (2020);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,10338-57-5

General procedure: To a solution of an aromatic ketone (3 mmol) in EtOH (15 mL), anaromatic aldehyde (3 mmol) and KOH (3 mmol) were added and the reaction mixture was stirred for 8 h at room temperature. On completion, the reaction mixture was concentrated under vacuum, the residue was dissolved in EtOAc (30 mL) and washed with water, then brine, dried over anhydrous Na2SO4 and concentrated under vacuum to afford the target compounds, which were purified by column chromatography on silica gel (hexane/EtOAc = 7/1).

The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Fu, Dong-Jun; Zhang, Sai-Yang; Song, Jian; Liu, Yin-Chao; Zhang, Li; Zhao, Ruo-Han; Zi, Xiao-Lin; Liu, Hong-Min; Zhang, Yan-Bing; Journal of Chemical Research; vol. 40; 10; (2016); p. 620 – 623;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem