Category: 10338-57-5

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 2b (1.75 g, 10 mmol) and triethyl 4-phosphonocrotonate (3.3 mL, 15 mmol) in THF (40 mL), sodium hydride (60% dispersion in mineral oil, 800 mg, 20 mmol) was carefully added at 0 C under Ar. After the reaction mixture was stirred at ambient temperature for 3 h, the reaction was quenched by adding ethanol (1 mL) and water (20 mL), and the product was extracted with EtOAc (3 x 20 mL). The organic layer was washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane/EtOAc [4:1]) to give 3b (1.9 g, 7.0 mmol, 70%) as yellow crystals., 10338-57-5

As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Kiyama, Masahiro; Iwano, Satoshi; Otsuka, Satoshi; Lu, Shijia W.; Obata, Rika; Miyawaki, Atsushi; Hirano, Takashi; Maki, Shojiro A.; Tetrahedron; vol. 74; 6; (2018); p. 652 – 660;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Chalcones analogs were synthesized by Claisen-Schmidt condensation reaction using appropriate equimolar amounts of substituted acetophenones and benzaldehydes in MeOH. NaOH was dissolved in the least amount of water and added dropwise (3mmol) (Scheme 1). Reactions were stirred overnight. All reactions were monitored by TLC using appropriate solvent or mixture of solvents. When the reaction was complete, the obtained precipitate was filtered, washed with cold methanol and dried under vacuum. The crude products were crystallized from different solvent systems based on their solubility or purified by column chromatography to give pure crystalline compounds.

10338-57-5, As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Elkhalifa, Dana; Siddique, Abu Bakar; Qusa, Mohammed; Cyprian, Farhan S.; El Sayed, Khalid; Alali, Feras; Al Moustafa, Ala-Eddin; Khalil, Ashraf; European Journal of Medicinal Chemistry; vol. 187; (2020);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 4-morpholinobenzaldehyde (1 mmol, 0.191 g) was added to a stirred mixture of malononitrile (1.5 mmol, 0.099 g), and catalytic amount of SSC NPs (0.012 g, 2 mol%) in ace-tonitrile (10 mL). It was allowed to the mixture to stir at 70 C under sonication about 25-60 minutes. After completion of the reaction (the reaction progress was monitored by TLC using EtOAc/n-hexane (1:1) as eluent), the reaction mixture was filtered to separate precipitate. Next, the pre-cipitate was dissolved in boiling ethanol and then was fil-trated to separate catalyst. Finally, pure crystalline product was obtained from filtrate. Since the catalyst is reusable, at the end of the reaction, it was washed by boiling methanol three times (3 × 2 mL), dried at 90 C for 2 h and re-used in further cycles. Also, in the following, we explain more details about reusability results of the catalyst on model reaction., 10338-57-5

The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Pourshojaei, Yaghoub; Nikzad, Maryam; Eskandari, Khalil; Darijani, Mohammad-Hossein; Hassanzadeh, Abdolreza; Faghih-Mirzaei, Ehsan; Asadipour, Ali; Croatica Chemica Acta; vol. 91; 1; (2018); p. 19 – 28;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

10338-57-5, General procedure: For the reactions, 4-piperidinone or corresponding ketones (1 mmol) and 2-bromobenzaldehyde or corresponding aldehydes(2.5 mmol) were dissolved in ethanol (10 mL). The mixture wasrefluxed at 78 C and added with 0.5 mL 40% NaOH or AcOH/HCl.Reactions were monitored by TLC, when the reactions were accomplished, cooled on ice. The products could precipitate or be purified by crystallization and column chromatography using PE/EA as the eluent. Among these compounds, A4, A6, C5, D1, D2, D3 and D4 were unreported.

10338-57-5 4-(Piperidin-1-yl)benzaldehyde 291354, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Jin, Rong; Chen, Qiuxiang; Yao, Song; Bai, Encheng; Fu, Weitao; Wang, Ledan; Wang, Jiabing; Du, Xiaojing; Wei, Tao; Xu, Haineng; Jiang, Chengxi; Qiu, Peihong; Wu, Jianzhang; Li, Wulan; Liang, Guang; European Journal of Medicinal Chemistry; vol. 144; (2018); p. 218 – 228;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: In a grinding jar, 4-(diphenylamino)benzaldehyde (0.015 mol, 4.10 g) were combined with [(4-ethenylphenyl)methyl] phosphonic acid diethyl ester (0.01 mol, 2.53 g), t-BuOK (0.02 mol, 2.76 g) and the 7 mm stainless steel balls. The grinding jar was placed in a planetary ball-mill and stirred at 550 runs per minute during 2 h at room temperature. Then 60 mL DCM was added in the jar and the mixture was washed twice with 200 mL water. The organic layer was dried over MgSO4, concentrated under vacuum. The residue was isolated by column chromatography on silica gel using petroleum ether/ethyl acetate (10:1) to afford 3.06 g of the titled compound as a light yellow needle crystal. Yield 80.2%., 10338-57-5

The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Huang, Jiu-Qiang; Cai, Zhi-Bin; Jin, Fan; Li, Sheng-Li; Tian, Yu-Peng; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 154; (2016); p. 164 – 170;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

10338-57-5, A mixture [OF 4-HYDRAZINO-1- (3-METHOXYPHENYL)-1 H-PYRAZOLO] [3, 4-d]pyrimidine (Intermediates Example T) (117 mg, 0.457 [MMOL), 4- (1-PIPERIDINYL) BENZALDEHYDE] (114 mg, 0.602 [MMOL),] and [PYRROLIDINE] (2 drops) in [ETOH] (10 mL) was heated at reflux for 12 h. The solid was filtered and washed with hexanes to yield product (195 mg, 98%) as a yellow solid. ‘H NMR (400 MHz, DMSO) 8 12.03 (s, [1 H),] 8.59 (s, 1H), 8.42 (s, [1 H),] 8.16 (s, [1 H),] 7.86- 7.84 (d+s, 2H), 7.62 (d, 2H), 7.45 (t, 1 H), 6.99 (d, 2H), 6.92 (m, [1] H), 3.82 (s, 3H), 3.27 (m, 4H), 1.57 (m, 6H) ppm; ES-MS m/z 428 (MH+).

10338-57-5 4-(Piperidin-1-yl)benzaldehyde 291354, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; SMITHKLINE BEECHAM CORPORATION; WO2004/9602; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 0.208 g. (0.002 mol) of malonic acid and 0.166 g.(0.001 mol) of 4-substituted benzaldehyde Ia-g and (5 mL) of pyridinewas prepared. Malonic acid is dissolved by shaking andwarming on a steam bath. Catalytic amount of piperidine was thenadded and the mixture was heated at 80-85 C for 1 h. After whichthe mixture was heated under reflux (109-115 C) for an additional3 h. The reaction mixture was then cooled and poured intocold water. The mixture was then acidified by slow addition of concentratedhydrochloric acid with stirring. The formed light crystalswere separated by filtration and washed 4 times with cold water.The crude acid was dissolved in a solution of 5% sodium hydroxide.The resulting solution was filtered, diluted with an additionalwater, and acidified by adding concentrated hydrochloric acid.The formed solid was filtered and washed with cold water. Thesolid was further purified by using methanol as the solvent of crystallizationto yield titled compounds IIIa-g.(E)-3-(4-(Piperidin-1-yl)phenyl) acrylic acid IIIc (E) Yield 87% as reddish purple solid, mp 110 C. IR: (U max, cm-1): 1594 (C=C), 1755 (C=O, COOH), 2928-3420 (OH, COOH). 1H NMR (400 MHz)(DMSO) delta: 1.54 (m, H, piperidine H3, H4, H5), 3.39 (t, 4H, piperidine H2, H6), 6.47 (d, 1H, CH=CH-COOH, J = 16 Hz), 7.01 (d, 2H, aromatic H3, H5, J = 8.8 Hz), 7.50 (d, 1H, CH=CH-COOH, J = 15.8 Hz), 7.65 (d, 2H, aromatic H2, H6, J = 8.8 Hz). MS: m/z (%): 231 (M+, 77%), 232 (M++1, 58%) and base peak at 209 (100%). Anal. Calcd for C14H17NO2: C, 72.70; H, 7.41; N, 6.06. Found: C, 72.84; H, 7.48; N, 6.19., 10338-57-5

10338-57-5 4-(Piperidin-1-yl)benzaldehyde 291354, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Abdel-Atty, Mona M.; Farag, Nahla A.; Kassab, Shaymaa E.; Serya, Rabah A.T.; Abouzid, Khaled A.M.; Bioorganic Chemistry; vol. 57; (2014); p. 65 – 82;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 8 (1 mmol), aromatic aldehyde (1 mmol) and piperdine (2 equiv.) in isopropyl alcohol was refluxed for 4-5 h. After completion of the reaction as seen from the TLC, (eluent 7:3 /hexane:ethyl acetate) the mixture was allowed to cool to room temperature. Then the reaction mixture was poured onto ice-water and neutralized with dilute HCl. The precipitated solid was filtered, washed with water and dried under vacuum.

10338-57-5, 10338-57-5 4-(Piperidin-1-yl)benzaldehyde 291354, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Ponnuchamy, Singanan; Kanchithalaivan, Selvaraj; Ranjith Kumar, Raju; Ashraf Ali, Mohamed; Soo Choon, Tan; Bioorganic and Medicinal Chemistry Letters; vol. 24; 4; (2014); p. 1089 – 1093;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The 4-alkyl(aryl)aminobenzaldehyde (1 mmol) was added to(RMe2Si)3CLi, R=H,Me (1 mmol) in THF under argon. The mixturewas reacted according to Tables 1 and 2. The reaction was quenchedwith H2O, extracted with CH2Cl2 and dried over Na2SO4. The solventwas evaporated under reduced pressure and the residue was purifiedby preparative column chromatography (n-hexane/ethylacetate) andthe corresponding products were obtained.

10338-57-5, The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Safa, Kazem Dindar; Nadimi, Sanaz; Alyari, Maryam; Journal of Chemical Research; vol. 38; 8; (2014); p. 498 – 501;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 5 or 7 in ethanol (3 mL/mmol) were added anaqueous solution of potassium hydroxide (50%, 5 mL/mmol) anda benzaldehyde derivative (8a-h, 1.5 equiv) The solution was stirredovernight until TLC showed complete disappearance of thestarting material. Ethanol was removed under reduced pressure.The residue was diluted into distilled water and acidified with anaqueous solution of hydrochloric acid (10%), then the mixturewas basified with saturated NaHCO3 solution to adjust the pH to7-8. The precipitate was filtered, washed with water and dried atroom temperature to afford the corresponding crude auronederivative as orange to dark red solid.

10338-57-5, As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Li, Yan; Qiang, Xiaoming; Luo, Li; Li, Yuxing; Xiao, Ganyuan; Tan, Zhenghuai; Deng, Yong; Bioorganic and Medicinal Chemistry; vol. 24; 10; (2016); p. 2342 – 2351;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem