Category: 10338-57-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

10338-57-5, General procedure: In a 100-mL round-bottom flask, ethyl 2-(7-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo- 2H-benzo[b][1,4]oxazin-4(3H)-yl)acetate (22) (1 g, 3.03 mmol, 1 equivalent) and triphenylphosphine (0.87 g, 3.33 mmol, 1.1 equivalent) were dissolved in ethanol (50 mL). After stirring at 25 C for 10-15 min, aromatic aldehyde (3.03 mmol, 1 equivalent) was added slowly along with stirring. The reaction mixture was allowed to stir for 24 h. The progress of the reaction was monitored by TLC (MeOH:CHCl3::1:19). On completion of the reaction, the solvent was evaporated under reduced pressure. The solid residue so obtained was purified by column chromatography (MeOH:CHCl3::1:49) to afford the desired benzoxazine-based arylidinyl succinimide derivative (23-36) in 64-80% isolated yield.

As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Sharma, Atul K.; Prasad, Suchita; Sharma, Sunil K.; Synthetic Communications; vol. 47; 20; (2017); p. 1854 – 1863;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: A flame-dried sealed tube equipped with exo-cyclic enol ether (0.3mmol) and 18-crown-6 (23.8mg, 0.09mmol) was pumped to vacuum and exchanged with nitrogen for three times. Aldehyde (0.45mmol), solution of t-BuOK in THF (60muL) and DMF (1mL) were then added successively under nitrogen atmosphere. The mixture was stirred at 110C and the reaction was monitored by TLC. After completion of the reaction, the mixture was cooled and concentrated aqueous solution of NH4Cl was added to quench the reaction. The resulting mixture was extracted with CH2Cl2 and the organic phase was washed with concentrated brine and dried over Na2SO4. The solvent was evaporated under reduced pressure, and the residue was passed through column chromatography on silica gel to afford the desired product C., 10338-57-5

The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Shang, Xue Song; Li, Deng Yuan; Li, Nian Tai; Liu, Pei Nian; Dyes and Pigments; vol. 114; C; (2015); p. 8 – 17;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a stirring mixture of 4-(2-morpholinoethoxy)benzaldehyde(0.235 g, 1 mmol) and malononitrile (0.132 g,2 mmol) dissolved in 10 cm3 EtOH, in the presence ofNiFe2O4 NPs (0.012 g, 5 mol%), dimedone (0.140 g,1 mmol) was added. The mixture was heated under refluxconditions for the time indicated in Table II. After completionof reaction which was found out by monitoring onTLC, the mixture was poured into boiling THF (10 mL)and then the catalyst was separated by a magnet, washedwith boiling acetone (5 cm3, and dried at 100 C for1 h to use in further cycles. The mixture was evaporatedto obtain crude product. In final step, crud product was recrystallized in boiling EtOH to afford crystalline pureproduct 4a., 10338-57-5

10338-57-5 4-(Piperidin-1-yl)benzaldehyde 291354, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Amiri, Mahnaz; Asadipour, Ali; Eskandari, Khalil; Faghih-Mirzaei, Ehsan; Khodadadi, Arash; Morsali, Laleh; Pourshojaei, Yaghoub; Shamsimeymandi, Reza; Talebi, Mahshid; Zolala, Fatemeh; Journal of Nanoscience and Nanotechnology; vol. 20; 5; (2020); p. 3206 – 3216;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Appropriate benzaldehyde (10 mmol) was dissolved in ethanol(20 mL). Sodium metabisulfite (15 mmol) in 5 mL water was addedin portion over 5 min. The reaction mixture was stirred at roomtemperature for 1 h and subsequently stirred at 4?C overnight.The precipitate formed was filtered and dried to afford sodiumbisulfite adducts (55-90%)., 10338-57-5

The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Yoon, Yeong Keng; Ali, Mohamed Ashraf; Wei, Ang Chee; Choon, Tan Soo; Khaw, Kooi-Yeong; Murugaiyah, Vikneswaran; Osman, Hasnah; Masand, Vijay H.; Bioorganic Chemistry; vol. 49; (2013); p. 33 – 39;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Potassium hydroxide (3.6 g, 64 mmol) and sodium hydroxide (2.4 g, 60 mmol) weremixed and quickly crushed in a porcelain dish. Then the corresponding aldehyde(15 mmol) was added and the mixture was heated on a hot-plate under stirring until thealdehyde melted and additionally 5 minutes. When liquid aldehydes were used, heatingwas continued until temperature reached 140C. After cooling, the crude solid productmixture was added to water (100 mL) and ice (30 g) and acidified with hydrochloric acidto pH 4. The precipitate was collected, dried and recrystallized from ethanol.

10338-57-5, As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Pietrzak, Marek; J?drzejewska, Beata; M?drzejewska, Dorota; Bajorek, Agnieszka; Organic Preparations and Procedures International; vol. 49; 1; (2017); p. 45 – 52;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Related benzaldehydes (7.5 mmol) was dissolved in EtOH(25 mL) and sodium metabisulfite (0.8 g) (in 5 mL of water) wasadded in portions. The reaction mixture was stirred vigorously andmore EtOH was added. The mixture was kept in a refrigerator for awhile. The white precipitate, the obtained salts were gained byfiltration, dried and used for the further steps without purificationand characterisation.

10338-57-5, The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Karaaslan, Cigdem; Doganc, Fatima; Alp, Mehmet; Koc, Asli; Karabay, Arzu Zeynep; Goeker, Hakan; Journal of Molecular Structure; vol. 1205; (2020);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.,10338-57-5

General procedure: The pyrone (30mmol) and morpholino (35mmol) are placed in a round bottom flask. Cyclohexane (45ml) was used as a solvent and p-toluenesulfonic acid as a catalyst, and the reaction conditions is refluxed in an oil bath at 90C condition 6h. Subsequently, at the rear end of the one-step reaction, cyclohexane was removed by rotary evaporation, and added difluorobenzaldehyde (30mmol) with ethanol as a solvent, then underwent an oil bath at 78C reflux condition monitored by thin-layer chromatography (TLC). Completion of the reaction is the end point of symmetry product just appeared. The reaction solution was cooled at room temperature, using 15% hydrochloric acid solution to adjust PH to acid field. Ethanol was removed by rotary evaporator and then extracted with ethyl acetate, purified by column chromatography. Unilateral product obtained reacted with different aldehydes dissolved in ethanol, 10% NaOH solution as catalyst to perform final products.

10338-57-5 4-(Piperidin-1-yl)benzaldehyde 291354, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Wu, Jianzhang; Wu, Shoubiao; Shi, Lingyi; Zhang, Shanshan; Ren, Jiye; Yao, Song; Yun, Di; Huang, Lili; Wang, Jiabing; Li, Wulan; Wu, Xiaoping; Qiu, Peihong; Liang, Guang; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 1321 – 1331;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a round bottom flask equipped with a magnetic stir bar, reflux condenser and a Soxhlet condenser filled with molecular sieves, DHA (4, 0.168 g, 1 mmol), 1 mmol of appropriate amino benzaldehyde 3a-e and catalytic amount of piperidine (8.5 mg, 0.1 mmol) were refluxed in dry toluene for 24 h. After complete reaction, toluene was removed under reduced pressure and residue was dissolved in CH2Cl2 and washed with water. Combined organic layer was dried over the anhydrous Na2SO4, and the solvent was removed in atmospheric pressure. Obtained crude solid was purified by recrystallization from EtOH.

10338-57-5, As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Teimuri-Mofrad, Reza; Rahimpour, Keshvar; Gholizadeh, Mohammad; Journal of the Iranian Chemical Society; vol. 17; 5; (2020); p. 1103 – 1109;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To solution of 4-((3-hydroxypiperidin-1-yl)methyl)benzohydrazide(9, 0.5 g, 2 mmol) in ethanol with catalytic amount of HClwas added the corresponding aldehyde (10, 2.4 mmol). The mixturewas stirred for 3 h at room temperature. Removal of the solventproduced a residue, which was purified using chromatographycolumn with the appropriate eluents systems.

10338-57-5, The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Dias Viegas, Flavia Pereira; de Freitas Silva, Matheus; Divino da Rocha, Miguel; Castelli, Maisa Rosa; Riquiel, Mariana Maximo; Machado, Rafael Pereira; Vaz, Sarah Macedo; Simoes de Lima, Lais Medeiros; Mancini, Karla Cristine; Marques de Oliveira, Patricia Cruz; Morais, Elida Parreira; Gontijo, Vanessa Silva; da Silva, Fernanda Motta R.; D’Alincourt da Fonseca Pecanha, Dora; Castro, Newton Goncalves; Neves, Gilda A.; Giusti-Paiva, Alexandre; Vilela, Fabiana Cardoso; Orlandi, Lidiane; Camps, Ihosvany; Veloso, Marcia Paranho; Leomil Coelho, Luis Felipe; Ionta, Marisa; Ferreira-Silva, Guilherme Alvaro; Pereira, Rodrigo Machado; Dardenne, Laurent E.; Guedes, Isabella Alvim; de Oliveira Carneiro Junior, Wellerson; Quaglio Bellozi, Paula Maria; Pinheiro de Oliveira, Antonio Carlos; Ferreira, Fabio Furlan; Pruccoli, Letizia; Tarozzi, Andrea; Viegas, Claudio; European Journal of Medicinal Chemistry; vol. 147; (2018); p. 48 – 65;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.,10338-57-5

General procedure: To a stirred solution of aldehyde (10mmol) (4-(dimethylamino)benzaldehyde, 4-(1-piperidinyl)benzaldehyde, 4-(4-morpholinyl)benzaldehyde or 4-(diphenylamino)benz-aldehyde) in EtOH (75mL), ketone (20mmol) (2-acetylpyridine, 2-acetylthiazole or 2-acetylpyrazine) was added. Then KOH (1.54g, 27.5mmol) and NH3 (aq) (35mL) were added to the reaction mixture. The solution was stirred at room temperature for 24h. The solid was collected by filtration and washed with H2O. Recrystallization from ethanol (1, 4, 7, 10) or toluene (2, 3, 5, 6, 8, 9, 11, 12) afforded a crystalline solid.

As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Palion-Gazda, Joanna; Machura, Barbara; Klemens, Tomasz; Szlapa-Kula, Agata; Krompiec, Stanis?aw; Siwy, Mariola; Janeczek, Henryk; Schab-Balcerzak, Ewa; Grzelak, Justyna; Ma?kowski, Sebastian; Dyes and Pigments; vol. 166; (2019); p. 283 – 300;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem