Category: 10315-06-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10315-06-7,Methyl 1-benzylpiperidine-4-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: A 0.2 M solution of the corresponding methyl ester in aq NH4OH (28-30%) was stirred at r.t. for 16 h. The solvent was evaporated to affordthe amide, which was, in some cases, purified by silica gel chromatography. The known amides 3, 33 5a,34 5b, 6c 5h,35 11a,36 11b,37 11c,3611e,38 11h,4 11i,39 11j,39 13,40 14,41 20,42 and 2343 were synthesized following the general procedure described above. Compound 5e was synthesized following the literature.44

10315-06-7, 10315-06-7 Methyl 1-benzylpiperidine-4-carboxylate 11436222, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Keita, Massaba; Vandamme, Mathilde; Paquin, Jean-Francois; Synthesis; vol. 47; 23; (2015); p. 3758 – 3766;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10315-06-7,Methyl 1-benzylpiperidine-4-carboxylate,as a common compound, the synthetic route is as follows.

To A SOLUTION OF BULI (12. 4 ML OF A 1. 6 M SOLUTION IN HEXANE, 19. 8 MMOL) IN THF (25 mL) COOLED TO-78 C, ACETONITRILE (1 ML) WAS ADDED DROPWISE UNDER ARGON atmosphere. After stirring the resulting suspension for 5 min AT-78 C, A SOLUTION of methyl 1-BENZYLPIPERIDINE-4-CARBOXYLATE (2. 0 G, 8. 1 MMOL, OBTAINED IN THE previous section) IN THF (5 ML) WAS ADDED DROPWISE AND STIRRED FOR 30 min AT-78 C. It was allowed to reach room temperature and stirred at this temperature overnight. 1 N HCI WAS ADDED TO ADJUST THE PH TO 7 and the aqueous phase was extracted with CHCI3. The organic phase was dried over NA2S04 and concentrated to dryness, to afford 1. 92 G OF THE DESIRED COMPOUND IN A SOLID orange form (YIELD : 98%)., 10315-06-7

The synthetic route of 10315-06-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; J. URIACH Y COMPANIA S.A.; WO2004/76450; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10315-06-7, Methyl 1-benzylpiperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of the corresponding b-carboline-3-acid methyl ester(1 mmol), NaOH (4 mmol), C2H5OH (5 ml) and H2O (10 ml) was refluxed for 3 h, and the ethanol was removed on the rotary evaporator.The mixture was neutralized (pH = 5) with 5 N HCl and cooled. The precipitate was collected, washed well with H2O and dried in vacuum. The material was used without further purificationfor the following steps., 10315-06-7

10315-06-7 Methyl 1-benzylpiperidine-4-carboxylate 11436222, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Wang, Jin; Wang, Zhi-Min; Li, Xue-Mei; Li, Fan; Wu, Jia-Jia; Kong, Ling-Yi; Wang, Xiao-Bing; Bioorganic and Medicinal Chemistry; vol. 24; 18; (2016); p. 4324 – 4338;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10315-06-7,Methyl 1-benzylpiperidine-4-carboxylate,as a common compound, the synthetic route is as follows.

Dried to 30L jacketed reactor was slowly purged with nitrogen, the 1.87kg1-benzyl-4-piperidine carboxylic acid methyl ester (8mol) and 2.0kg of toluene into a reactor, with stirring, cooled to an internal temperature of -5 . The resulting red aluminum – morpholine complex (approximately 8.8mol) was dropped to control the reaction temperature at 0 , 1 mixture liquid is completed, 0 reaction was continued for 30min. Was added slowly prepared 4N sodium hydroxide solution (containing 1.1kgNaOH), control the internal temperature not higher than 20 , the addition was completed, stirring was stopped, the organic layer was washed with water (11.0kg / times, 4 times), organic layer was concentrated under reduced pressure at 75 deg.] C and concentrated until no solvent was distilled off to give 1-benzyl-4-piperidine carbaldehyde 1.57kg, as a pale yellow oily liquid. Yield: 96.5%. HPLC: 99.03%

10315-06-7, The synthetic route of 10315-06-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Shanghai Goldentree Resin Powder Co., Ltd.; Zhu, Ben; (8 pag.)CN105693596; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10315-06-7, Methyl 1-benzylpiperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of V-2 A solution of V-l (20 g, 85.72 mmol) in 80 mL of THF (dry) was added dropwise over lh to a solution of LDA (60 mL, 2.0 M, 120 mmol) in 80 mL of THF (dry) at 0C. The resultant mixture was stirred at 0C for 30 min, and then added to a pre-cooled (0C) solution of N- fluorobenzenesulfonimide (28.38 g, 90 mmol) in 120 mL of THF (dry). The resulting reaction mixture was stirred at 0C for 30 min, and then at 25C overnight. After dilution by 400 mL of EtOH, the mixture was washed with water (100 mL x3) and brine (100 mL), dried and concentrated. The crude was purified by silica gel chromatography (PE to PE/DCM=2/1 to DCM to DCM/MeOH=200/l) to afford V-2 (6 g, yield: 28%) as a colorless oil., 10315-06-7

The synthetic route of 10315-06-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; SUZHOU SHANGZHI BIOTECH LIMITED; CHENG, Xueheng; WO2014/8629; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10315-06-7,Methyl 1-benzylpiperidine-4-carboxylate,as a common compound, the synthetic route is as follows.

5L reaction flask to dry slowly purged with nitrogen, will 233.3g1-benzyl-4-piperidine carboxylic acid methyl ester (1mol) and 240ml of toluene into a reactor, with stirring, cooled until the internal temperature at about -5 . The resulting red aluminum – morpholine complex (approximately 2.6mol) was dropped to control the reaction temperature between -5 ~ 0 . 3h addition was complete, the reaction was continued insulation 2h. Was added slowly prepared 4N sodium hydroxide solution (containing 360gNaOH), control the internal temperature not higher than 20 , the addition was completed, stirring was stopped, the organic layer was washed with water (1500ml / times, 4 times), the organic layer was concentrated at 75 concentrated under reduced pressure until no solvent was evaporated to give 1-benzyl-4-piperidinemethanol 201.6g, as a pale yellow oily liquid. Yield: 98.2%. HPLC: 99.30%

10315-06-7, As the paragraph descriping shows that 10315-06-7 is playing an increasingly important role.

Reference：
Patent; Shanghai Goldentree Resin Powder Co., Ltd.; Zhu, Ben; (8 pag.)CN105693596; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10315-06-7, Methyl 1-benzylpiperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of the corresponding b-carboline-3-acid methyl ester(1 mmol), NaOH (4 mmol), C2H5OH (5 ml) and H2O (10 ml) was refluxed for 3 h, and the ethanol was removed on the rotary evaporator.The mixture was neutralized (pH = 5) with 5 N HCl and cooled. The precipitate was collected, washed well with H2O and dried in vacuum. The material was used without further purificationfor the following steps.

10315-06-7, 10315-06-7 Methyl 1-benzylpiperidine-4-carboxylate 11436222, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Wang, Jin; Wang, Zhi-Min; Li, Xue-Mei; Li, Fan; Wu, Jia-Jia; Kong, Ling-Yi; Wang, Xiao-Bing; Bioorganic and Medicinal Chemistry; vol. 24; 18; (2016); p. 4324 – 4338;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10315-06-7, Methyl 1-benzylpiperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Dried to 30L jacketed reactor was slowly purged with nitrogen, the 1.87kg1-benzyl-4-piperidine carboxylic acid methyl ester (8mol) and 2.0kg of toluene into a reactor, with stirring, cooled to an internal temperature of -5 . The resulting red aluminum – morpholine complex (approximately 8.8mol) was dropped to control the reaction temperature at 0 , 1 mixture liquid is completed, 0 reaction was continued for 30min. Was added slowly prepared 4N sodium hydroxide solution (containing 1.1kgNaOH), control the internal temperature not higher than 20 , the addition was completed, stirring was stopped, the organic layer was washed with water (11.0kg / times, 4 times), organic layer was concentrated under reduced pressure at 75 deg.] C and concentrated until no solvent was distilled off to give 1-benzyl-4-piperidine carbaldehyde 1.57kg, as a pale yellow oily liquid. Yield: 96.5%. HPLC: 99.03%

10315-06-7, As the paragraph descriping shows that 10315-06-7 is playing an increasingly important role.

Reference：
Patent; Shanghai Goldentree Resin Powder Co., Ltd.; Zhu, Ben; (8 pag.)CN105693596; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10315-06-7, Methyl 1-benzylpiperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Prepared with LiHMDS as Base: A solution of product from Example 32B (2 g, 6 mmol) in tetrahydrofuran (15 ml) was cooled to -20 to -22 C. under a nitrogen atmosphere. A solution of lithium hexamethyldisilazide (LiHMDS) (1.0M in THF, 7.2 ml, 7.2 mmol) was added, dropwise, maintaining the temperature at -20 to -22 C. After the addition, the solution was stirred at -20 to -22 C. for 2 hours. A solution of product from Example 7 (2.26 g, 8 mmol) in tetrahydrofuran (10 ml) was added, dropwise, at -20 to -22 C. The reaction was stirred for an additional 2.5 hours while maintaining the low temperature. The mixture was quenched with saturated ammonium chloride (15 ml) and extracted with ethyl acetate (3*10 ml). The organic extract was dried over anhydrous magnesium sulfate, filtered through silica pad and concentrated to a small residual volume. n-Heptane (10 ml) was add and the solution was left overnight at room temperature to produce 2.4 g (69%) of the product as white crystals. HPLC: 90% pure., 10315-06-7

10315-06-7 Methyl 1-benzylpiperidine-4-carboxylate 11436222, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Sandanayaka, Vincent P.; Zask, Arie; Venkatesan, Aranapakam M.; Baker, Jannie L.; Krishnan, Lalitha; Megati, Sreenivasulu; Zeldis, Joseph; US2002/99035; (2002); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10315-06-7,Methyl 1-benzylpiperidine-4-carboxylate,as a common compound, the synthetic route is as follows.

B. Synthesis of l-benzylpiperidine-4-carboxylic acid hydrochloride; [0096] Methyl l-benzylpiperidine-4-carboxylate (11.6 g, 50 mmol) was refluxed with 6N HCl (140ml) overnight. The reaction mixture was concentrated to remove water. The residue compound (l-benzylpiperidine-4-carboxylic acid hydrochloride, 12 g) was obtained by heating and drying under vacuum in the oven.

10315-06-7, 10315-06-7 Methyl 1-benzylpiperidine-4-carboxylate 11436222, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; NEUROMED PHARMACEUTICALS LTD.; WO2008/31227; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem