Category: 1022150-11-3

Reference of 1022150-11-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1022150-11-3, Name is (R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate, molecular formula is C27H30N6O3. In a Patent，once mentioned of 1022150-11-3

The present invention relates to polymorphic forms of N-{4-[3-chloro-4-(3-fluoro-benzyloxy)phenylamino]-quinazolin-6-yl}-acrylamide p-toluenesulfonate with the characteristic X-ray powder diffraction data as stated in the description, preparation methods thereof, pharmaceutical compositions comprising the same and the use thereof.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 1022150-11-3 is helpful to your research. Reference of 1022150-11-3

Reference：
Piperidine – Wikipedia,
Piperidine | C5H24051N – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. name: (R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 1022150-11-3

The present invention discloses a two-c amino-acetyl amino and aza Base kuikui zuo lin apperception compound in preparation for preventing or treating tumor application of the medicament, in particular the preparation for preventing or treating human leukemia application of the medicament, and the Young person morning to inhibit leukemia cell HL – 60 active has a remarkable effect. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.name: (R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate, you can also check out more blogs about1022150-11-3

Reference：
Piperidine – Wikipedia,
Piperidine | C5H24059N – PubChem

 

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1022150-11-3, molcular formula is C27H30N6O3, introducing its new discovery. Computed Properties of C27H30N6O3

Phenyl […] compound and its preparation method, pharmaceutical composition, drug use (by machine translation)

The invention provides a phenylurea coupling quinazoline compound or a pharmaceutically acceptable salt thereof represented by formula (I), wherein R1 represents H, represents Br, Cl or F, represents -CH3, -CH2-CH3, -CH2(CH3)2 or -CF3, represents -O-CH3, -O-CH2-CH3 or -O-CH2(CH3)2, or represents -C[triple bond]CH or -C[triple bond]N; n1 is 1, 2, 3, 4 or 5; one of R2 and R3 is a group represented by formula (II); R4 represents H, represents Br, Cl or F, represents -CH3, -CH2-CH3, -CH2(CH3)2 or -CF3, represents -O-CH3, -O-CH2-CH3 or -O-CH2(CH3)2, represents -NH2, or represents -NO2; n2 is 1, 2, 3, 4 or 5; and the other one of R2 and R3 represents H, -O-CH3, -O-CH2-CH3, -O-CH2(CH3)2, or the following groups.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Computed Properties of C27H30N6O3, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1022150-11-3

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H24064N – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Formula: C27H30N6O3. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 1022150-11-3

TARGETED COVALENT PROBES AND INHIBITORS OF PROTEINS CONTAINING REDOX-SENSITIVE CYSTEINES

Covalent, irreversible small-molecule inhibitors that modify the sulfenyl form (i.e., sulfenic acid, RSOH and sulfenamide, RSNR’2) of therapeutically important proteins (particularly kinases and phosphatases) are disclosed, where the compositions include a compound having a substituted aryl or heterocyclic core structure that promotes binding interactions with a specific protein, and a nucleophilic reaction center (carbon, nitrogen, sulfur, or phosphorous) that is capable of forming a covalent bond with a sulfenic acid- or sulfenamide-modified cysteine residue in the protein. Methods for synthesizing these compounds are also disclosed, as well as methods of using them for determining the bioactivity of a chemical composition comprising an active compound toward a specific protein and for determining the potency of an inhibitor against a specific protein.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C27H30N6O3, you can also check out more blogs about1022150-11-3

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H24122N – PubChem

 

Application of 1022150-11-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1022150-11-3, Name is (R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate, molecular formula is C27H30N6O3. In a Article£¬once mentioned of 1022150-11-3

Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. Part 4: Structure-activity relationships for substituents on the quinazoline moiety of 4-[4-(N-substituted(thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives

Here, we investigated the structure-activity relationships of the 6,7-dimethoxyquinazoline moiety. With regard to exploration of positions and varieties of substituents on the quinazoline ring, 6,7-dialkoxy substitution was optimal. This study suggests the possibility of further modifications for this moiety.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 1022150-11-3 is helpful to your research. Application of 1022150-11-3

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H24120N – PubChem

 

Electric Literature of 1022150-11-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1022150-11-3, Name is (R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate, molecular formula is C27H30N6O3. In a Patent£¬once mentioned of 1022150-11-3

Method of treating or inhibiting colonic polyps

This invention provides a method of treating or inhibiting colonic polyps in a mammal in need thereof which comprises administering to said mammal a compound having the formula wherein:X is phenyl which is optionally substituted;R and R1 are each, independently, hydrogen, halogen, alkyl, alkoxy, hydroxy, or trifluoromethyl;R2 is hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl;Y is a radical selected from the group consisting of R3 is independently hydrogen, alkyl, carboxy, carboalkoxy, phenyl, or carboalkyl;n=2-4;or a pharmaceutically acceptable salt thereof, with the proviso that each R3 of Y may be the same or different.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Electric Literature of 1022150-11-3, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1022150-11-3

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H24045N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ name: (R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate, Which mentioned a new discovery about 1022150-11-3

H based on the quinazoline structure2S donor compound and and its application (by machine translation)

The invention discloses a based on the quinazoline structure H2 S donor compound and and its application, its are of the formula (I) indicated by the compound or its pharmaceutically acceptable salt, wherein Ar is substituted or non-substituted phenyl, substituted ethylenically: halogen, nitro, C1 – 4 Alkyl, C1 – 4 Haloalkyl, C1 – 4 Alkoxy, C1 – 4 Haloalkyl oxy in one or several; X is C1 – 4 Alkoxy, B – NH – or A – CH2 CO – NH – group, Y is H, B – Cn H2n O – or A – Cn H2n O – group, respectively A or B H2 S donor group, n is 1 – 5 integer, and X is C1 – 3 Alkoxyl basetime Y is not H. The present invention is based on the synthesis of a series of 4 – anilinoquinazoline structure of H2 S donor compound, through the H2 S and 4 – anilinoquinazoline derivatives of synergistic effects, thereby improving the antitumor activity of the medicament. (by machine translation)

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, name: (R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 1022150-11-3

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H24088N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ Formula: C27H30N6O3, Which mentioned a new discovery about 1022150-11-3

O-toluene amino acetyl amino methoxy phenyl and aza * base kuikui zuo lin apperception compound in the preparation of a drug for treating cervical carcinoma in the application of the (by machine translation)

The invention discloses a O-toluene amino acetyl amino methoxy phenyl and aza Base kuikui zuo lin apperception compound in preparation for preventing or treating tumor application of the medicament, in particular for the production in the prevention or treatment of human cervical carcinoma in the medicament application, its Siha activity inhibiting human cervical carcinoma cell has a remarkable effect. (by machine translation)

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Formula: C27H30N6O3, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 1022150-11-3

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H24075N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1022150-11-3,(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Compound (IV) (Pgi = Pg2 = Boc) (2.93 g, 5 mmol) was dissolved in MeOH (15 ml), then 33% HC1 (3 ml) was added, and the reaction mass was heated at 50C for 4 st with intensive stirring (note: a foam is forming during the reaction due to isolation of gaseous by-products). After completion of the reaction the resulting solution was cooled to room temperature and evaporated to dryness (note: the vapor contains HC1). Saturated Na2CO3 solution (5 ml) was added to the dry residue and the mixture was extracted with EtOAc (3 x 10 ml). The extract was dried over Na2SO4 and evaporated in vacuum. Yield 1.89 g (98%), white amorphous mass., 1022150-11-3

As the paragraph descriping shows that 1022150-11-3 is playing an increasingly important role.

Reference£º
Patent; LATVIAN INSTITUTE OF ORGANIC SYNTHESIS; LEBEDEVS, Antons; PONOMARJOVS, Jurijs; VARACEVA, Larisa; CERNAKS, Dmitrijs; CERNOBROVIJS, Aleksandrs; LAVRINOVICS, Edvards; (15 pag.)WO2017/39425; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

1022150-11-3, (R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 2.5g (5.1mmol) of formula 10 was added to the methanol solution in 25ml of hydrochloric acid, stirred at room temperature 2hour. Concentrated under reduced pressure, the residue was added 30ml of water, extracted with ethyl acetate, the organic phase was washed with 5% aqueousSodium hydroxide solution was washed until neutral. The organic phase was concentrated under reduced pressure to give a pale yellow oil 1.82g, yield 92%

1022150-11-3, The synthetic route of 1022150-11-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Okuura Dayton (Shanghai) Pharmaceutical Co., Ltd.; Yu, Libing; Guo, Maojun; Yang, Qingang; Ren, Huasen; (19 pag.)CN105622613; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem