Category: 1001353-92-9

Electric Literature of 1001353-92-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1001353-92-9, Name is (R)-1-Methylpiperidin-3-amine, molecular formula is C6H14N2. In a Patent，once mentioned of 1001353-92-9

The present invention relates to novel thienopyrrolotriazinacetamide compounds of Formula (I): wherein R1, R2 and R3 are defined herein, which inhibit NOD-like receptor protein 3 (N1rP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by N1rP3.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1001353-92-9

Reference：
Piperidine – Wikipedia,
Piperidine | C5H1676N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Safety of (R)-1-Methylpiperidin-3-amine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1001353-92-9, Name is (R)-1-Methylpiperidin-3-amine, molecular formula is C6H14N2. In a Patent, authors is ，once mentioned of 1001353-92-9

A compound according to Formula I or II: wherein R1, R1b, R2, L1, and L2 and L2b are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. Safety of (R)-1-Methylpiperidin-3-amine

Reference：
Piperidine – Wikipedia,
Piperidine | C5H1678N – PubChem

1001353-92-9, (R)-1-Methylpiperidin-3-amine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Int 13 (342 mg, 1 .001 mmol) and (R)-1 -methylpiperidin-3-amine (149 mg, 1 .301 mmol) in DMF (8 ml.) was added DIPEA (0.524 ml_, 3.00 mmol), HOBt (169 mg, 1 .101 mmol) and EDC (249 mg, 1 .301 mmol). The solution was stirred at RT overnight. The reaction mixture was diluted with 5% Na2CC>3 solution and extracted with EtOAc. The organic layer was washed twice with 5% Na2CC>3 solution, then brine. A white precipitate which formed between the layers was filtered off. The remaining organic extract was dried over Na2S04, filtered and evaporated to give an off-white solid after trituration with DCM. This crude product was combined with the first precipitate and further purified by crystallization from hot MEK to provide the title compound as white crystalline solid. 1 H NMR (400 MHz, DMSO-d6) d (ppm) 7.98 (d, J = 8.0 Hz, 1 H), 7.91 (s, 1 H), 7.53 (s, 1 H), 6.09 (s, 1 H), 4.54 (d, J = 1 .9 Hz, 2H), 3.81 – 3.66 (m, 1 H), 2.66 – 2.57 (m, 1 H), 2.48 – 2.45 (m, overlapping with DMSO signal, 1 H) 2.13 (s, 3H), 1 .98 – 1 .87 (m, 1 H), 1 .86 – 1 .76 (m, 1 H), 1 .71 – 1 .60 (m, 2H), 1 .58 (s, 6H), 1 .52 – 1 .38 (m, 1 H), 1 .27 – 1 .1 1 (m, 1 H). LC-MS: Rt = 0.69 min; MS m/z [M+H]+ 438.2

1001353-92-9, The synthetic route of 1001353-92-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; FARADY, Christopher; GOMMERMANN, Nina; JANSER, Philipp; MACKAY, Angela; MATTES, Henri; STIEFL, Nikolaus Johannes; VELCICKY, Juraj; (148 pag.)WO2020/21447; (2020); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem