New CNS agent precursors. A simple and efficient route for synthesis of 6-aminomethyl-4,5,6,7-tetrahydrobenzofuran-4-ones as conformationally constrained butyrophenone analogs was written by Casariego, Isabel;Masaguer, Christian F.;Ravina, Enrique. And the article was included in Tetrahedron Letters in 1997.Application In Synthesis of 4-(2-Methoxyphenyl)piperidine This article mentions the following:
Starting from 3,4,5-trimethoxybenzoic acid, we described a practical and efficient five-step synthesis of 6-aminomethyl-4,5,6,7-tetrahydrobenzofuran-4-ones as new CNS agent precursors in an overall yield of 20%. In the experiment, the researchers used many compounds, for example, 4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8Application In Synthesis of 4-(2-Methoxyphenyl)piperidine).
4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Application In Synthesis of 4-(2-Methoxyphenyl)piperidine
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem