Sequential Conia-ene-type cyclization and Negishi coupling by cooperative functions of B(C6F5)3, ZnI2, Pd(PPh3)4 and an amine was written by Cao, Min;Yesilcimen, Ahmet;Prasad, Soumil;Genova, Jason;Myers, Tanner;Wasa, Masayuki. And the article was included in Organic & Biomolecular Chemistry in 2020.Application In Synthesis of 1,2,2,6,6-Pentamethylpiperidine This article mentions the following:
Authors disclose a method for sequential Conia-ene-type cyclization/Negishi coupling for the union of alkynyl ketones and aryl iodides. This process is promoted through cooperative actions of Lewis acidic B(C6F5)3, ZnI2, Pd-based complex, and a Bronsted basic amine. The three Lewis acid catalysts with potential overlapping functions play their independent roles as activators of carbonyl group, alkyne moiety, and alkenyl zinc intermediate, resp. A variety of 1,2,3-substituted cyclopentenes I (R1 = n-Bu, Ph, 2-MeOC6H4, 2-furyl, 2-naphthyl; R2 = Me, Et, n-Pr, n-Bu; Ar = Ph, 2-thienyl, 1-naphthyl, etc.) can be synthesized with high efficiency. In the experiment, the researchers used many compounds, for example, 1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0Application In Synthesis of 1,2,2,6,6-Pentamethylpiperidine).
1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Application In Synthesis of 1,2,2,6,6-Pentamethylpiperidine
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem