Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Khan, Farman Ali, once mentioned the application of 79725-98-7, Name is (4-Oxo-5-(palmitoyloxy)-4H-pyran-2-yl)methyl palmitate, molecular formula is C38H66O6, molecular weight is 618.93, MDL number is MFCD23140972, category is piperidines. Now introduce a scientific discovery about this category, SDS of cas: 79725-98-7.
Structural basis of binding and justification for the urease inhibitory activity of acetamide hybrids of N-substituted 1,3,4-oxadiazoles and piperidines
In present, we have performed the Michaelis-Menten kinetics studies of urease inhibitors (6a-o), having basic skeleton of acetamide hybrids of N-substituted 1,3,4-oxadiazoles and piperidines. From the Lineweaver-Burk plot, Dixon plot and their secondary replots, it has been confirmed that all the compounds have inhibited the enzyme competitively with K-i values of in range from 3.11 +/- 0.2 to 5.20 +/- 0.7 mu M. Compound 6a was found to have lowest K-i among the series, while compounds 6d, 6e, 6g and 6i were found subsequently the excellent K-i values after 6a. Molecular docking has supported their types of inhibitions and structure activity-relationship. Most frequently, the nitro group oxygen atoms were found in contact with nickel ions of the active site. Moreover, all the compounds were subjected to toxicity tests and were found nontoxic against human neutrophils and plants, respectively. (C) 2020 Elsevier B.V. All rights reserved.
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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem