A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Product Details of 41979-39-9, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 41979-39-9, Name is Piperidin-4-one hydrochloride, molecular formula is C5H10ClNO. In a Article, authors is Lagisetty, Pallavi，once mentioned of 41979-39-9
3,5-Bis(2-fluorobenzylidine)-4-piperidone or EF24 is a potent anticancer derivative of curcumin. Using an amine derivative of EF24, we synthesized a hydrazinonicotinic acid conjugate, EFAH, for Tc-99m radiolabelling and single photon emission tomography imaging. The aqueous solubility of EFAH (3.5mg/mL) was significantly more than that of EF24 (1.2mg/mL); the octanol/water partition coefficient of EFAH was estimated at log P=0.33. As an antiproliferative agent, EFAH was as effective as EF24 in suppressing the proliferation of H441, MiaPaCa-2 and Panc-1 cells. Daily intraperitoneal injection of EFAH (5mug) for 3weeks in mice carrying xenografts of Panc-1 pancreatic cancer showed a mean tumour volume reduction of 79%; the tumour weight decreased by 82% in the treated group. For imaging and biodistribution, EFAH was labelled with Tc-99m (98% RCY) and intravenously administered in rats. Approximately 23.7% and 14.3% of injected dose accumulated in liver and intestine, respectively, suggesting that EFAH is mostly eliminated by hepatobiliary route. The results indicate that HYNIC modification of EF24 for Tc-99m radiolabelling does not affect its antiproliferative efficacy. For the first time, a visual biodisposition of EF24 in a live animal model has been demonstrated. Such knowledge could be of benefit in developing therapeutic curcuminoids, such as EF24.
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Reference：
Piperidine – Wikipedia,
Piperidine | C5H6273N – PubChem