Synthetic Route of 41661-47-6, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 41661-47-6, Name is 4-Piperidinone,introducing its new discovery.
In the present study, a series of mono-carbonyl analogues of curcumin were designed and synthesized by deleting the reactive beta-diketone moiety, which is responsible for the pharmacokinetic limitation of curcumin. We demonstrated that 4 of 9 curcumin analogues were selective inhibitors of human and rodent 11beta-HSD1. The level of this inhibitor was 4-20 times more than that of curcumin. Curcumin analogues weakly inhibited 11beta-HSD2, and further analyses revealed that these compounds were highly selective, favoring 11beta-HSD1. These 4 curcumin analogues are potential therapeutic agents for type-2 diabetes by targeting 11beta-HSD1. The compound 8 displays anti-diabetic properties in diabetic mice induced by streptozocin and high-fat-diet (STZHFD).
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Reference：
Piperidine – Wikipedia,
Piperidine | C5H280N – PubChem