Related Products of 3466-80-6, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 3466-80-6, Name is 2-Phenylpiperidine, molecular formula is C11H15N. In a Article£¬once mentioned of 3466-80-6
Removal of the pyridine directing group from alpha-substituted N-(pyridin-2-yl)piperidines obtained via directed Ru-catalyzed sp3 C-H functionalization
Two strategies, “hydrogenation-hydride reduction” and “quaternization-hydride reduction”, are reported that make use of mild reaction conditions (room temperature) to efficiently remove the N-pyridin-2-yl directing group from a diverse set of C-2-substituted piperidines that were synthesized through directed Ru-catalyzed sp3 C-H functionalization. The deprotected products are obtained in moderate to good overall yields irrespective of the strategy followed, indicating that both methods are generally equally effective. Only in the case of 2,6-disubstituted piperidines, could the “quaternization-hydride reduction” strategy not be used. The “hydrogenation-hydride reduction” protocol was successfully applied to trans- and cis-2-methyl-N-(pyridin-2-yl)-6-undecylpiperidine in a short synthetic route toward (¡À)-solenopsin A (trans diastereoisomer) and (¡À)-isosolenopsin A (cis diastereoisomer). The absolute configuration of the enantiomers of these fire ant alkaloids could be determined via VCD spectroscopy.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Related Products of 3466-80-6, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3466-80-6, in my other articles.
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H9248N – PubChem