Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. Recently I am researching about ONE-POT SYNTHESIS; N-SULFONYLFORMAMIDINES; SULFONYL AMIDINES; TERTIARY-AMINES; METAL-FREE; INHIBITORS; DESIGN; ROUTE; INTERCEPTION; FORMAMIDINES, Saw an article supported by the Program of Young Talent Development in Yangtze Normal University [2018QNRC16]; Project for Basic Research and Frontier Exploration of Science and Technology Commission of Chongqing [cstc2019jcyjmsxml275, cstc2016jcyjA0056]; Science and Technology Research Program of the Chongqing Education Commission of China [KJQN201901422]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Gou, Q; Liu, ZN; Cao, TW; Tan, XP; Shi, WB; Ran, M; Cheng, FX; Qn, J. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane
Herein, we describe an efficient copper-catalyzed coupling of sulfonamides with alkylamines to synthesize (E)-N-sulfonylformamidines. The reaction is accomplished under mild conditions without the use of a corrosive acid or base as an additive. It tolerates a broad scope of substrates and generates the products with exclusive (E)-stereoselectivity.
Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Gou, Q; Liu, ZN; Cao, TW; Tan, XP; Shi, WB; Ran, M; Cheng, FX; Qn, J or concate me.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem