On April 20, 2006, Burgey, Christopher S.; Deng, James Z.; Potteiger, Craig; Williams, Theresa M. published a patent.Recommanded Product: Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate The title of the patent was Preparation of oxohomopiperidinyl oxospiropiperidinepyrrolopyridinecarboxamides and related compounds as calcitonin gene-related peptide (CGRP) receptor antagonists.. And the patent contained the following:
Title compounds [I; A = bond, C(R2)2, O, SOm, NR2; B = [C(R2)2]n; R1, R2 = H, (substituted) alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl; pairs of R2 may form rings; R3 = H, F, cyano, (substituted) alkyl, CO2R4; R4 = H, (substituted) alkyl, fluoroalkyl, cycloalkyl, aryl, heteroaryl, PhCH2; X = C, S; Y = O, (R4)2, NCN, NHSO2Me, NCONH2; or Y = O2 when X = S; J = bond, C(R6)2, O, NR6; V = bond, C(R6)2, O, SOm, NR6, NR6NR6, etc.; Q = CR7a, C(R7A)2, CO, SOm, N, NR7a; T = CR7b, C(R7b)2, CO, SOm, N, NR7b; R6 = H, halo, OR4, CO2R4, alkyl, cycloalkyl, (substituted) aryl, heteroaryl, heterocyclyl, etc.; R7a, R7b = R2; R7aR7b = atoms to form cycloalkyl, aryl, heterocyclyl, heteroaryl rings; m = 0-2; n = 0, 1], were prepared for treatment of headache (no data). Thus, (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one (preparation given) and 4-nitrophenyl chloroformate in THF at 0° were treated with Et3N; after 60 min. spiro[piperidine-4,3′-pyrrolo[2,3-b]pyridin]-2′(1’H)-one dihydrochloride (preparation given) and Et3N in CHCl3 were added followed by warming to room temperature to give title compound (II). The experimental process involved the reaction of Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate(cas: 883984-95-0).Recommanded Product: Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate
The Article related to oxoazepanyl oxospiropiperidinepyrrolopyridinecarboxamide preparation cgrp receptor antagonist, headache treatment oxohomopiperidinyl spiropiperidinepyrrolopyridinecarboxamide preparation and other aspects.Recommanded Product: Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem