Repeated idiopathic anaphylaxis caused by povidone was written by Bruusgaard-Mouritsen, Maria Anna;Mortz, Charlotte;Winther, Lone;Garvey, Lene Heise. And the article was included in Annals of Allergy, Asthma, & Immunology in 2021.Formula: C32H39NO4 The following contents are mentioned in the article:
Povidone, also known as polyvinylpyrrolidone (PVP) and E1201, is a synthetic, hydrophilic polymer used as an excipient in cosmetics, pharmaceutical products and food. It is used as a lubricant and antiseptic in eye drops and contact lenses and is found in the disinfectant povidone iodine (Betadine, Alcon Nordic, Copenhagen,Denmark). Allergy to povidone is rare but has been reported with increasing frequency. In this case report we present a case of allergy to povidone of a 49-yr-old man and was referred for allergy investigation in Jan. 2019 after repeated allergic reactions over a 10-yr period, diagnosed after repeated allergic reactions, over several years, to chem. unrelated drugs and idiopathic exposures. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Formula: C32H39NO4).
2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Formula: C32H39NO4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem