Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, HPLC of Formula: C8H11N5O, 14047-28-0, Name is (R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol, SMILES is C[C@@H](O)CN1C=NC2=C(N)N=CN=C12, belongs to piperidines compound. In a document, author is Wagener, Tobias, introduce the new discover.
Accessing (Multi)Fluorinated Piperidines Using Heterogeneous Hydrogenation
Fluorinated piperidines are desirable motifs for pharmaceutical and agrochemical research. Nevertheless, general synthetic access remains out of reach. Herein, we describe a simple and robust cis-selective hydrogenation of abundant and cheap fluoropyridines to yield a broad scope of (multi)fluorinated piperidines. This protocol enables the chemoselective reduction of fluoropyridines while tolerating other (hetero)-aromatic systems using a commercially available heterogenous catalyst. Fluorinated derivatives of important drug compounds are prepared, and a straightforward strategy for the synthesis of enantioenriched fluorinated piperidines is disclosed.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 14047-28-0. HPLC of Formula: C8H11N5O.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem