Recently I am researching about C-H BONDS; ALPHA,BETA-UNSATURATED CARBONYL-COMPOUNDS; DIRECT BETA-ARYLATION; INTRAMOLECULAR AMINATION; AEROBIC DEHYDROGENATION; C(SP(3))-H BONDS; GAMMA-AMINATION; ARYL KETONES; PALLADIUM; FUNCTIONALIZATION, Saw an article supported by the National Key Research and Development Program of China [2017YFA0206801]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21431008, u1505242, 21702205]; Chinese Academy of SciencesChinese Academy of Sciences [XDB20000000, XDB10040304, ZDRW-CN-2016-1]. Published in NATURE PUBLISHING GROUP in LONDON ,Authors: Hu, R; Chen, FJ; Zhang, XF; Zhang, M; Su, WP. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. Computed Properties of C7H13NO2
Metal-catalyzed beta-C-H functionalization of saturated carbonyls via dehydrogenative desaturation proved to be a powerful tool for simplifying synthesis of valuable beta-substituted carbonyls. Here, we report a copper-catalyzed dehydrogenative gamma-C(sp(3))-H amination of saturated ketones that initiates the three-component coupling of saturated ketones, amines and N-substituted maleimides to construct polysubstituted anilines. The protocol presented herein enables both linear and alpha-branched butanones to couple a wide spectrum of amines and various N-substituted maleimides to produce diverse tetra- or penta-substituted anilines in fair-to-excellent yields with good functional group tolerance. The mechanism studies support that this ketone dehydrogenative gamma-C(sp(3))-H amination was triggered by the ketone alpha,beta-dehydrogenation desaturation that activates the adjacent gamma-C(sp(3))-H bond towards functionalization. This alpha,beta-dehydrogenation desaturation-triggered cascade sequence opens up a new avenue to the remote C(sp(3))-H functionalization of saturated ketones and has the potential to enable the rapid syntheses of complex compounds from simple starting materials.
Welcome to talk about 177-11-7, If you have any questions, you can contact Hu, R; Chen, FJ; Zhang, XF; Zhang, M; Su, WP or send Email.. Computed Properties of C7H13NO2
Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem