With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.952681-82-2,2-(1′-(tert-Butoxycarbonyl)spiro[chroman-2,4′-piperidine]-4-yl)acetic acid,as a common compound, the synthetic route is as follows.
952681-82-2, Preparation of 5.8:[0250] To a solution of the carboxylic acid 5.7 (433 mg, 1.2 mmol) in acetonitrile (15 mL) was added ./V,./V-diisopropylethylamine (0.86 mL, 4.9 mmol) and diethylamine (1.6) (0.36 mL, 3.5 mmol). The reaction mixture was cooled with ice-bath and TBTU (463 mg, 1.44 mmol) was added portionwise to the reaction mixture. The reaction mixture was stirred at room temperature overnight. The reaction mixture was concentrated, dissolved in ethyl acetate. The organic solution was washed with saturated aqueous sodium bicarbonate and dried over sodium sulfate. Evaporation of the solvent gave the crude product, which was chromato graphed using ethyl acetate/hexane (1:1) as eluent. Yield: 80%.1H NMR (400 MHz, CDCl3) delta 7.20 (m, IH), 7.10 (m, IH), 6.88 (m, 2H), 3.81 (m, 2H), 3.56-3.30 (m, 6H), 3.08 (m, IH), 2.92 (dd, IH), 2.40 (dd, IH), 2.12 (m, IH), 1.83-1.62 (m, 3H), 1.48 (s+m, HH), 1.20 (t, 3H).
952681-82-2 2-(1′-(tert-Butoxycarbonyl)spiro[chroman-2,4′-piperidine]-4-yl)acetic acid 56965736, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; ADOLOR CORPORATION; WO2007/118151; (2007); A2;,
Piperidine – Wikipedia
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