85908-96-9, N-Boc-2-Piperidone is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
85908-96-9, Step 2 tert-butyl 3,3-diallyl-2-oxopiperidine-l-carboxylate [0360] To a solution of tert-butyl 2-oxopiperidine- 1 -carboxylate (8.22 g, 41.3 mmol) in anhydrous THF (80 mL) was added LiHMDS (1.0 M in THF, 103 mL, 103 mmol) dropwise under nitrogen atmosphere at -78 C. The reaction mixture was stirred for 20 min and 3- bromoprop-l-ene (10.7 mL, 124 mmol) was added. The resulting mixture was stirred for 15 min, and then allowed to warm to rt, and quenched with water (15 mL), concentrated in vacuo. The residue was diluted with water (30 mL) and extracted with EtOAc (50 mL x 3). The combined organic phases were washed with brine (50 mL), then dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/PE (v/v) = 1/50) to give the title compound as yellow oil (3.95 g, 35%). MS (ESI, pos. ion) m/z: 224.2 [(M-C4H8)+H]+; NMR (600 MHz, CDCb): delta (ppm) 5.72 (ddt, J =16.5, 10.5, 7.0 Hz, 2H), 5.06 (d, J = 10.5 Hz, 2H), 5.03 (d, J= 16.5 Hz, 2H), 3.55 (t, J = 5.8 Hz, 2H), 2.46 (dd, J = 13.6, 7.0 Hz, 2H), 2.21 (dd, J = 13.6, 7.0 Hz, 2H), 1.75 (m, 4H), 1.48 (s, 9H).
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Reference：
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD; XI, Ning; LI, Minxiong; HU, Haiyang; DAI, Weilong; LI, Xiaobo; WANG, Tingjin; WU, Yanjun; (136 pag.)WO2016/190847; (2016); A1;,
Piperidine – Wikipedia
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