With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79099-07-3,1-Boc-4-Piperidone,as a common compound, the synthetic route is as follows.
79099-07-3, A mixture of tert-butyl 4-oxopiperidine-1-carboxylate (15.0 g, 0.075 mol) and DMFDMA (9.87 g, 0.0829 mol) in DMF (100 mL) was heated at 90 C with stirring overnight. The resulting mixture was then concentrated in vacuo and diluted with water (100 mL). The resulting mixture was extracted with EA (30 mL) for three times. The combined organic layer was washed with water, dried over anhydrous Na2SO4 and concentrated in vacuo to give the crude tert-butyl 3-(dimethylaminomethylene)-4-oxo-piperidine-1-carboxylate (13 g) as yellow oil, which was used in the next step directly.
79099-07-3 1-Boc-4-Piperidone 735900, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; WANG, Jianhua; WANG, Min; YANG, Song; (84 pag.)WO2018/83106; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem