With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79098-85-4,3-(Piperidin-4-yl)indolin-2-one hydrochloride,as a common compound, the synthetic route is as follows.,79098-85-4
EXAMPLE 179 4-(2-Oxo-2,3-dihydroindol-3-yl)-1-(3-phenoxypropyl)piperidine STR215 From a mixture of 4-[2-oxo-2,3-dihydroindol-3-yl)piperidine hydrochloride (198 mg, 0.73 mmol), 3-phenoxy-propyl chloride (476 mg, 2.22 mmol) and K2 CO3 (138 mg) in toluene (15 mL) was obtained 170 mg (70%) of the title compound as a yellow oil, 1 H NMR (CDCl3): 1.42-1.50 (m, 2H), 1.79-2.03 (m, 6H), 2.10-2.15 (m, 1H), 2.47-2.52 (m, 2H), 2.90-3.04 (m, 2H), 3.408 (d, 1H, J=3.5), 7.001 (t, 1H, J=7.5), 7.022 (t, 1H, J=7.5), 7.23-7.29 (m, 3H), 7.909 (s, 1H). The hydrochloride mp 182-3 C.
The synthetic route of 79098-85-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Warner-Lambert Company; Cocensys, Incorporated; US6124323; (2000); A;,
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