With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78056-60-7,1-Acetyl-4-piperidineacetic acid,as a common compound, the synthetic route is as follows.
Reference Example 28 To a THF solution of (1-acetylpiperidin-4-yl)acetic acid were added under room temperature triethylamine and pivaloyl chloride, followed by stirring at room temperature for 1 hour. The reaction mixture was filtered and concentrated. Then, 3-cyclohexanecarbonyl-2-ethylamino-6-methylpyridine was added to the residue, followed bystirring at 150C for 14 hours. Ethanol and sodium methoxide were added to the product obtained by working up the reaction mixture, and the whole was heated under reflux for 1 hour. Thereafter, the reaction mixture was worked up and purified in a usual manner to obtain 3-(1-acetylpyridin-4-yl)-4-cyclohexyl-1-ethyl-7-methyl-1,8-naphthyridin-2(1H)-one as a colorless solid. MS: 396., 78056-60-7
The synthetic route of 78056-60-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; YAMANOUCHI PHARMACEUTICAL CO. LTD.; EP1225173; (2002); A1;,
Piperidine – Wikipedia
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