With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.769944-79-8,4-(4-Bromophenyl)piperidine hydrochloride,as a common compound, the synthetic route is as follows.
The tert-butyl 4-[4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)phenyl]piperidine-l- carboxylate used as a reagent for this reaction was prepared as follows:Di-tert-butyl dicarbonate (0.914 ml) was added in one portion to 4-(4- bromophenyl)piperidine hydrochloride (1.00 g) and triethylamine (1.260 ml) in DCM (34 ml) at ambient temperature. The resulting solution was stirred for 70 minutes. The reaction mixture was evaporated and washed with isohexane. The filtrate was evaporated and there was thus obtained tert-butyl 4-(4-bromophenyl)piperidine-l-carboxylate (1.191 g); Mass Spectrum: (M-tBu)+H+ 281.28; RT 2.33 min; NMR Spectrum: (DMSOd6) 7.53 (2H, d), 7.27 (2H, d), 4.12 (2H, d), 2.75 – 2.96 (2H, m), 2.68 – 2.79 (IH, m), 1.79 (2H, d), 1.47 (9H, s), 1.44 – 1.58 (2H, m).
769944-79-8, The synthetic route of 769944-79-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; ASTRAZENECA AB; WO2009/7390; (2009); A2;,
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