With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.768-66-1,2,2,6,6-Tetramethylpiperidine,as a common compound, the synthetic route is as follows.,768-66-1
General procedure: A dry and nitrogen-flushed-10 mL round bottom flask equipped with a magnetic stirrer and a septum was charged with amine 2 (0.5 mmol, 1 equiv) and was evacuated and refilled with nitrogen three times. Dry THF (0.5 mL) was added and the reaction flask was again evacuated and refilled with nitrogen three times. The reaction mixture was cooled to 0 C, and BuLi solution (0.55 or 1.05 mmol, 2.45 M in THF, 1.1 or 2.1 equiv) was added. After 5 min of stirring, 1a or 1b (0.5 mmol, 1 equiv) was added at 0 C and the reaction was checked by 19F NMR with PhOCF3 as internal standard. Reaction was quenched with saturated aqueous NaHCO3 and EtOAc was added. The organic phase was washed with water, dried over Na2SO4, and concentrated in vacuo. The crude residue was purified by flash chromatography to give the expected product.
The synthetic route of 768-66-1 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Alazet, Sebastien; Ollivier, Kevin; Billard, Thierry; Beilstein Journal of Organic Chemistry; vol. 9; (2013); p. 2354 – 2357;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem