768-66-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.768-66-1,2,2,6,6-Tetramethylpiperidine,as a common compound, the synthetic route is as follows.
Step 1. Preparation of the tetramethylpiperidide solution. 1.9 mL (11.7 mmol; 3 eq. ) of 2,2, 6,6-tetramethylpiperidine was dissolved in 4 mL of anhydrous THF; the solution was cooled TO-80C and then 3.9 mL (9.8 mmol; 2.5 eq) of a 2.5 M solution BuLi in Hexane were added. The mixture was stirred for 2h at 0C.Step 1. Preparation of the tetramethylpiperidide solution. 1.9 mL (11.7 mmol; 3 eq. ) of 2,2, 6,6-tetramethylpiperidine was dissolved in 3 mL of anhydrous THF; the solution was cooled TO-80C and then 3.9 mL (9.8 mmol; 2.5 eq) of a 2.5 M solution BuLi in Hexane were added. The mixture was stirred for 2h at 0C.
The synthetic route of 768-66-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.p.A.; WO2005/7603; (2005); A2;,
Piperidine – Wikipedia
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