With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.768-66-1,2,2,6,6-Tetramethylpiperidine,as a common compound, the synthetic route is as follows.,768-66-1
The 131 mg 2, 2, 6, 6 – tetramethyl hexahydro pyridine plus 1.5 ml anhydrous toluene, cooling to 0 C, dropwise 0.37 ml 2 . 5M BuLi, in canada finishes 0 C to 5 C stirring reaction 30min, then dropwise 1 ml 0 . 9MEt2AlCl (toluene) solution, in canada finishes 0 C to 5 C stirring reaction 40min, then the instillment contains 70 mg (0.232mmol) embodiment 6 compound of 1.5 ml of a toluene solution, canada finishes C – 5 C stirring for 20 hours. TLC display raw material spot disappears, carefully dropwise methanol stopped reaction, adds full and NH4Cl, extraction with ethyl ether, the combined extract, water washing, water-free Na2SO4Drying, filtering, the filtrate is silica gel short column purification, petroleum ether/EtOAc (10/1) elution, to obtain the product 50 mg (71.4%), Rf=0.35 (petroleum ether/EtOAc=4/1).
The synthetic route of 768-66-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Zhejiang Aoxiang Pharmaceutical Co., Ltd.; Zheng Zhiguo; (45 pag.)CN103304375; (2017); B;,
Piperidine – Wikipedia
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