61869-08-7, (3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
61869-08-7, EXAMPLE 3 Preparation of paroxetine hydrochloride hemihydrate 11.58 kg of paroxetine free base was charged into a reactor containing 81.06 L of ethyl acetate and stirred for about 15 minutes at about 30 C. to form a clear solution. The reaction mass was filtered through a filtration system containing an online filter (5 micron polypropylene cloth), a 0.45 micron cartridge polypropylene filter, and a 0.2 micron cartridge polypropylene filter, and the filtration system was washed with 34.74 L of ethyl acetate. 2.895 L of 36% aqueous hydrochloric acid was added slowly to the filtrate over about 30 minutes at about 28-33 C. The reaction mass was stirred for about 1 hour, 45 minutes at about 28-30 C. It was then cooled to about 1 C. and maintained for about 1 hour, 30 minutes at about 0-2 C. The reaction mass was centrifuged and the wet cake washed with 23.16 L of chilled ethyl acetate. The wet solid was dried at 30 C. for about 1 hour, 15 minutes under a vacuum of about 690 mm Hg. The solid was further dried at about 58 C. under a vacuum of about 690 mm Hg for about 4 hours to get 10.9 kg of the paroxetine hydrochloride.; EXAMPLE 4 Purification of paroxetine hydrochloride hemihydrate 10.9 kg of the paroxetine hydrochloride obtained in Example 3 above was charged into a clean, dry reactor containing 76.3 L of acetone and the contents were heated to reflux. 4.564 L of water was added to the reaction suspension at reflux for about 60 minutes and stirred at reflux for about 20 minutes to form a clear solution. The reaction mass was cooled slowly to about 33 C. in 2 hours and then stirred for 1 hour at about 30-33 C. 32.7 L of n-heptane was charged into the reactor and stirring was continued for about 1 hour, 30 minutes. The reaction mass was cooled to about 2 C. and stirred for about 2 hours. The reaction mass was centrifuged and wet cake was washed with 6.54 L of chilled acetone. The wet solid was dried under vacuum of about 690 mm Hg at about 30 C. for about 2 hours and then at about 55-57 C. for about 4 hours. The resultant solid was milled in a micronizer (Manufacturer: Microtech Engineering company, Model: M-50) with an air pressure of 0.5 kg/cm2 at a feed rate of 7 kg/hour and then sieved through a 10 mesh sieve yielding 8.7 Kg of paroxetine hydrochloride hemihydrate with particle size distribution: D10=2.37 mum; D50=11.1 mum; and D90=30.6 mum.
61869-08-7 (3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine 44274603, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; Thippannachar, Vijayavitthal Mathad; Jayantilal, Pravinchandra Vankawala; Elati, Chandrasekhar Ravi Ram; Kolla, Naveen Kumar; Chlamala, Subrahmanyeswara Rao; US2006/264637; (2006); A1;,
Piperidine – Wikipedia
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