With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50607-30-2,Piperidine-2,4-dione,as a common compound, the synthetic route is as follows.,50607-30-2
[0239] 2,4-piperidinedione (1.0g, 8.84mmol) was dissolved in MeOH. NaBH4 (0.5g, 13.26mmol) was added at 0°C,stirred at 0°C for 30min, and the reaction mixture was then placed at room temperature and stirred for 1h. TLC (DCM/Me-OH) was employed to monitor the reaction. After the reaction completed, it was quenched by adding water and dried byspinning. Column chromatography afforded white solid powder 0.8g, yield 80.0percent.[0240] 1H NMR (400 MHz, DMSO-d6) delta 7.52-7.28 (s, 1H), 5.06-4.78 (d, J = 3.5 Hz, 1H), 4.03-3.78 (dp, J = 7.2,3.9,3.3Hz, 1H),3.28-3.14 (m, 1H),3.09-2.91 (dtt, J = 7.4, 5.2, 2.2 Hz, 1H), 2.42-2.25 (dd, J = 17.1,4.7 Hz, 1H), 2.13-1.93 (dd, J= 17.1, 6.1 Hz, 1H), 1.83-1.66 (ddt, J = 12.7, 7.9,3.6 Hz, 1H), 1.69-1.47 (dt, J = 13.2, 6.4 Hz, 1H).MS(ESI)m/z :[(M+1)+,117.1],
The synthetic route of 50607-30-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Zhe Jiang Jutai Pharmaceutical Co., Ltd; YANG, Yushe; XUE, Tao; DING, Shi; GUO, Bin; EP2947085; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem