With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50534-49-1,N,N-Dimethylpiperidin-3-amine,as a common compound, the synthetic route is as follows.
EXAMPLE DDD86292 2,6-Dichloro-4-[2-(3-dimethylamino-pyrrolidin-1-yl)-pyridin-4-yl]-N-(1,3,5-trimethyl-1 H-pyrazol-4-yl)-benzenesulfonamide Prepared by heating the chloropyridine of intermediate 12 (250 mg, 0.58 mmol) with 3-dimethylaminopiperidine (200 mul) in EtOH (1.5 ml) at 155 C. for 1 h according to the method of DDD86213 to give the title compound as a white powder (150 mg, 0.29 mmol, 49%). deltaH (CDCl3, 300K) 8.48 (1H, d J 5.1 Hz), 7.49 (2H, s), 7.39 (1H, d J 4.7 Hz), 7.32 (1H, s), 3.76-3.46 (6H, s br), 3.63 (3H, s), 3.46-3.39 (1H, m), 2.75 (2H, s br), 2.28 (2H, s br), 2.05 (3H, s), 1.85 (3H, s), 1.56 (2H, s br). m/z (ES+, 70V) 523.2 (MH+)., 50534-49-1
As the paragraph descriping shows that 50534-49-1 is playing an increasingly important role.
Reference£º
Patent; Brand, Stephen; Wyatt, Paul; Thompson, Stephen; Smith, Victoria; Bayliss, Tracy; Harrison, Justin; Norcross, Neil; Cleghorn, Laura; Gilbert, Ian; Brenk, Ruth; US2011/312921; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem