496807-97-7, 3,3-Difluoropiperidine hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of compound 97 (1 equiv) in benzene (10 vol) was added TEA (1.5 equiv) and DPPA (1.2 equiv). The reaction mixture was stirred at 50 C for 1 h and then cooled to room temperature. 3,3-difluoropiperidine hydrochloride (4 equiv) and TEA (8 equiv) was added to the reaction mixture and stirred at 80 C for 16 h. After completion of the reaction, the reaction mixture was concentrated and the residue was purified by preparative HPLC to give compound 40. 1H MR (400 MHz, DMSO-de) delta 8.63 (s, 1H), 8.18 – 8.11 (s, 2H), 7.42 – 7.20 (m, 4H), 7.01 – 6.97 (m, 1H), 5.55 – 5.42 (m, 1H), 5.34 – 5.30 (m, 1H), 5.14 – 5.09 (m, 1H), 4.48 – 4.23 (m, 3H), 4.14 – 4.08 (m, 1H), 3.93 – 3.76 (m, 4H), 3.52 – 3.51 (m, 2H), 2.49 (s, 3H), 2.09 – 1.99 (m, 3H), 1.71 – 1.69 (m, 2H).
496807-97-7, The synthetic route of 496807-97-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; (337 pag.)WO2017/35349; (2017); A1;,
Piperidine – Wikipedia
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