Brief introduction of 41661-47-6

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, COA of Formula: C5H9NO, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 41661-47-6

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， COA of Formula: C5H9NO, Which mentioned a new discovery about 41661-47-6

We previously reported the design and discovery of three series of 5-carbon linker-containing mono-carbonyl analogs of curcumin (MCACs) as excellent anti-inflammatory agents. In continuation of our ongoing research, we designed and synthesized the fourth series of MCACs, whose central linker is a piperid-4-one. Their inhibitory effects against IL-6 production were evaluated in lipopolysaccharide (LPS)-stimulated macrophages. Among them, compounds F8, F29, F33, F35, and F36 exhibited the IC50 values under 5 muM. The structure-activity relationship was discussed. Mechanistically, F35 and F36 dose-dependently prevented LPS-induced NF-kappaB and ERK activation. Finally, pretreatment with F35 and F36 significantly protected the C57B/L6 mice from LPS-induced septic death. Together, these data present a series of new analogs of curcumin as promising anti-inflammatory agents.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, COA of Formula: C5H9NO, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 41661-47-6

Reference：
Piperidine – Wikipedia,
Piperidine | C5H36N – PubChem