With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.373603-88-4,3,3-Dimethylpiperidin-4-ol,as a common compound, the synthetic route is as follows.
General procedure: In an oven-dried RB flask, compound 6c (250mg, 1.01mmol) and formaldehyde solution, 37-41wt.% in water (0.15mL, 2.02mmol) were mixed in glacial acetic acid (5mL). Morpholine (220.4mg, 2.53mmol) was added drop wise at 0C. The resulting mixture was stirred at room temperature for 12h. After completion of the reaction, the excess solvent was evaporated to dryness under reduced pressure. The residue was neutralized with 10% NaHCO3 solution, the solid formed was collected by filtration, washed with water and dried. The crude product was purified by silica gel column chromatography to provide title compound.
373603-88-4, The synthetic route of 373603-88-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Jose, Gilish; Kumara, T. H. Suresha; Nagendrappa, Gopalpur; Sowmya; Jasinski, Jerry P.; Millikan, Sean P.; More, Sunil S.; Janardhan, Bhavya; Harish; Chandrika; Journal of Molecular Structure; vol. 1081; (2015); p. 85 – 95;,
Piperidine – Wikipedia
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