With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3612-20-2,1-Benzylpiperidin-4-one,as a common compound, the synthetic route is as follows.
To a solution of compound 29-1A (19.04 g, 211.36 mmol), t-BuOK (29.65 g, 264.20 mmol) in Toluene (250 mL) was added compound 29-1 (20 g, 105.68 mmol) at 90 C and stirred at 90 C for 2 hours. TLC (PE: EA= 2: 1, Rf= 0.7) showed compound 29-1 was consumed. The mixture was filtered, the organic layers was diluted with NH4C1 (aq) (300 mL), extracted with EA (100 mL*3) and concentrated in vacuo to afford the title compound (30 g, crude), as yellow oil. LC-MS: [M+H]+ =248.3.
3612-20-2, As the paragraph descriping shows that 3612-20-2 is playing an increasingly important role.
Reference：
Patent; NOVARTIS AG; BECKWITH, Rohan Eric John; JIANG, Hua; WANG, Ce; (0 pag.)WO2020/58913; (2020); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem