With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3433-37-2,2-(Hydroxymethyl)piperidine,as a common compound, the synthetic route is as follows.
3433-37-2, A. (l-Benzylpiperidin-2-yl)methanol (compound 13) To a stirred solution of piperidine-2 -methanol (12; 6 g, 52.09 mmol) in dimethylformamide (DMF, 50 mL) were added successively K2CO3 (10.78 g, 78.14 mmol) and benzyl bromide (6.85 mL, 57.30 mmol) at 0¡ãC and the mixture stirred at rt for 16 hours. The reaction mixture was then filtered and the filtrate was concentrated. The residue was dissolved in EtOAc and the organic layer was washed with water and brine solution. The organic layer was dried over Na2S04, filtered and concentrated. The crude material was purified by chromatography on 230-400 mesh silica gel eluting with 30percent EtOAc-hexane to provide compound 13. Yield: 6.0 g (56.6percent); 1H-NMR (400 MHz, CDC13): delta 7.37-7.21 (m, 5H), 4.05 (d, J= 13 Hz, 1H), 3.85 (dd, J= 11, 4 Hz, 1H), 3.50 (dd, J= 11, 4 Hz, 1H), 3.30 (d, J= 13 Hz, 1H), 2.88-2.83 (m, 1H), 2.69 (brs, 1H), 2.47-2.43 (m, 1H), 2.17-2.11 (m, 1H), 1.70-1.54 (m, 4H), 1.40-1.33 (m, 2H).
The synthetic route of 3433-37-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ENDO PHARMACEUTICALS INC.; GUPTA, Sandeep; PRIESTLEY, Tony; LAPING, Nicholas, James; WO2014/28675; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem