With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3433-37-2,2-(Hydroxymethyl)piperidine,as a common compound, the synthetic route is as follows.
To a stirred solution of piperidin-2-ylmethanol (1.5 g, 13.02 mmol) in dichloromethane (25 mL) was added DIPEA (6.82 mL, 39.1 mmol). After stirring for 5 min Boc20 (3.63 mL, 15.63 mmol) was added and the mixture was stirred at RT overnight. The mixture was quenched with water and diluted with DCM (50 mL). The organic layer was separated, dried over Na2S04 and concentrated to give tert- butyl 2-(hydroxymethyl)piperidine-l-carboxylate (2 g, 9.29 mmol, 71percent crude yield) as a colorless oil, which was taken to the next step without further purification. 1H NMR (400 MHz, CDCh) ppm delta 4.27-4.28 (m, IH), 3.80-3.82 (m, IH), 3.75-3.77 (m, IH , 3.56-3.58 (m, IH), 2.63 (t, J = 7.20 Hz, IH), 1.55-1.55 (m, 5H), 1.43 (s, 9H).
The synthetic route of 3433-37-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; VRUDHULA, Vivekananda, M.; PAN, Senliang; RAJAMANI, Ramkumar; NARA, Susheel, Jethanand; KARATHOLUVHU, Maheswaran, Sivasamban; MAISHAL, Tarun, Kumar; DITTA, Jonathan, L.; DZIERBA, Carolyn, Diane; BRONSON, Joanne, J.; MACOR, John, E.; WO2015/116060; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem