With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.309956-78-3,(R)-tert-Butyl piperidin-3-ylcarbamate,as a common compound, the synthetic route is as follows.
In 100 mL of DMF, 4.53 g (10 mmol) of compound 5 and 2.41 g (12 mmol) of compound 6, 2.76 g (20 mmol) of K2CO3 were added, and the reaction was performed at 75 C for 16 hours.Monitor the progress of the reaction by TLC, cool to room temperature, filter, and add 500 mL of distilled water to the filtrate.A solid was precipitated, and the filtrate was cooled to 0 C, filtered, washed with water, and dried to obtain 8-[(3R) -3-tert-butoxycarbonylamino-1-piperidinyl] -7- (2-butynyl) -3, 7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl) methyl] -1H-purine-2,6-dione 5.21 g (9.1 mmol) in a yield of 91%.
As the paragraph descriping shows that 309956-78-3 is playing an increasingly important role.
Reference£º
Patent; Shenzhen The Second People Hospital; Chen Xuhong; Tan Hui; Yan Dewen; Li Haiyan; Liu Xueting; Ou Huiting; Cai Jinlin; (8 pag.)CN110590780; (2019); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem